1] The first novel anticoagulant (NOAC) and direct thrombin inhibitor (DTI), lepirudin
, originates from 1998, when its intravenous form was approved for the use of clinically relevant heparin-induced thrombocytopenia (HIT).
The present in vitro experiments were planned to determine whether the DTIs lepirudin
and argatroban and the predominantly factor Xa inhibitors enoxaparin, danaparoid, and fondaparinux could interfere with the result of LA testing based on dPT.
Sanofi ([double dagger]) Clexhane/enoxaparin Injection ILA01 34751 OLC56 ILA53 OLC07 12255 Pfizer ([section]) Fragmin/dalteparin Injection sodium 12339A01 12338A01 12327B01 12257A01 12444A01 12122C01 74774D51 74871B51 74779G51 74871B51 74743C52 74755A51 74832A52 74832A01 X08580 ([paragraph]) Wockhart (#) Monoparin Injection PK40319 3090 Hepsal Flushing 5000090 91180 1069 Leo ** Heparin Intravenous sodium flushing DD7314 CC4338 Ceigene ([dagger])([dagger]) Refludan/ Powder used for Lepirudin
, solution for 25561611A ([double dagger]) injection/infusion ([double dagger]) Total quantity tested NA Producer, Excipient proprietary name/other names, batch or lot no.
Heparin was stopped, and alternate anticoagulation with lepirudin
The bivalent DTIs include bivalirudin and lepirudin
, and bind both the active site and exosite 1 of thrombin.
Available DTIs include argatroban, lepirudin
(Refludan), and bivalirudin (Angiomax).
The use of direct thrombin inhibitors (DTI) such as Lepirudin
or Argatroban is becoming more widely accepted as means of anticoagulating HIT and other hypercoagulable patients.
0] nonane-7-carbaldehyde 1AY6 Homosapiens HHO:[1-(hydroxymethyleneamino)-8-hydroxy-octane] 1BA8 Homosapiens Hirugen, CVS1578 1CA8 Homosapiens 3GA:[3-piperidyl-n-guandino-l-alaninal] 1FPC Homosapiens EPI:[4-ethylpiperidine] 1H8D Homosapiens HirudinI, Lepirudin
1H8I Homosapiens HirudinI, LepirudinTys 1LHC Homosapiens DP7[AC(D) phe-pro-boro-arg-OH] 1LHD Homosapiens DI2[AC-(D) phe-pro-borolys-OH] 1LHG Homosapiens DI5[AC-(D) phe-pro-borohomoornithine-OH] 1PPB Homosapiens Chloro Methyl Ketone 1TMT Homosapiens CGP50,856 (synthetic) 1TOM Homosapiens MIN: Methyl-Phe-Pro-Amino-Cyclohexylglycine 1UMA Homosapiens IN2: [N,N-Dimethylcarbamoyl-Alpha Azalysine] 1UVS Homosapiens BM12.
Heparin-induced thrombocytopenia with thromboembolic complications: metaanalysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin
and its therapeutic aPTT range.
HIT tedavisinde secilebilecek antikoagulanlar; bir heparinoid olan danaparoid, geri donusumsuz direk trombin inhibitoru rekombinant hirudin olan lepirudin
, geri donu sumlu direk trombin inhibitorleri bivalirudin, argatroban ve fondaparinuxtur .
Heparin-induced platelet antibodies were identified on the day after transfer; heparin was discontinued and lepirudin
is recombinant hirudin, and directly inhibits clot-bound thrombin, preventing its binding to fibrinogen.