Envelope sequence variation, neutralizing antibodies, and primate lentivirus
Chapters address lentivirus
tropism and disease, macrophages in HIV-1 infection, intracellular mechanisms for lentiviral restriction, simian-HIV and simian immunodeficiency virus models of HIV disease, host and viral determinants of feline immunodeficiency virus cell tropism and pathogenicity, equine infectious anemia virus and its pathogenesis, the bovine lentivirus
infections, and lentivirus
coinfections and superinfections, among other topics.
In preclinical studies, lentivirus
vectors developed by Cell Genesys, have demonstrated safe, efficient and long-lasting gene transfer into a variety of human cells including both dividing and non-dividing cells such as nerve, liver, muscle and bone marrow stem cells.
We found that GFP expression transduced by lentivirus
under control of synapsin developed faster and was more robust.
Despite these limitations, advancements in targeting and the ability of retroviruses such as lentivirus
to infect nondividing and dividing cells keep it at the forefront of viral gene therapy delivery systems.
Human immunodeficiency virus type 1 (HIV 1) is assigned to genus Lentivirus
, subfamily Orthoretrovirinae, family Retroviridae.
HERPES VIRUS AND LENTIVIRUS
MEDIATED GENE TRANSFER.
The vector used is based on a debilitated form of a lentivirus
, which contains an antisense sequence targeted to the envelope gene.
Indeed, SIV-infected sooty mangabeys may be spared, by their failure to mount significant antiviral immune responses, much of the indirect bystander damage seen in pathogenic primate lentivirus
infections that both contributes to accelerated CD4 depletion and compromises host immune regenerative capacity.
On the one hand, it could be argued that since there is no known mechanism by which retroviruses kill host cells and, as some panellists have argued, that the evidence that HIV is a retrovirus belonging to the lentivirus
family of RNA viruses is not compelling, it should therefore be concluded that HIV cannot be the primacy cause of Aids.
is especially attractive for gene therapy, according to lead investigator Pierre Charneau, PhD, because when it is used as a vector, it has the ability to transfer DNA into poorly-dividing or nondividing cells, such as nerve cells, blood stem cells, and liver and muscles cells.
This led to the discovery of a defined AIDS-causing lentivirus
now called HIV-2.