leader sequence


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leader region

or

leader sequence

a sequence of NUCLEOTIDES at the 5'-END of MESSENGER RNA (and on DNA), UPSTREAM of the start CODON for TRANSLATION. This sequence contains the RIBOSOME BINDING SITE but is not normally translated into a part of the PROTEIN of the GENE. In some cases it contains a regulatory region called an ATTENUATOR.

leader sequence

the nontranslated section of mRNA before the coding region.
References in periodicals archive ?
For murine hepatitis virus and several CoVs, an [approximately equal to]70bp leader sequence is added to the 5?
Between these two extremes of the arbitrary, resolutely nonnarrative coupling of image and sound, one sees all manner of footage from old propaganda films, especially from Vietnam and China (with the material often showing signs of damage), as well as a projection that with its many back-to-back leader sequence countdowns looks like a self-reflexive loop.
After introduction of the leader sequence into the mammalian expression vector pcDNA3.
Compositions of the invention are nucleotide sequences encoding a signal peptide sequence for a yeast secreted protein, an optional leader peptide sequence for a yeast secreted protein, a native propeptide leader sequence for a mature protein of interest, and a sequence for the mature protein of interest, all operably linked to a yeast promoter.
They appear to be translated as inactive prepeptides containing an N-terminal leader sequence and a C-terminal propeptide component.
The present study sought to map the sites of inhibition of in vitro translation of the movement protein by hybridizing a series of test ASOs to the 5' leader sequence of BMV RNA 3.
The leader sequence acts as a signal for the protein to enter the classical 'secretion' pathway, which routes proteins through cellular machinery called the Golgi apparatus and endoplasmic reticulum (ER) before being secreted outside the cell.
Posiphen represses -Synuclein mRNA translation by its 5' leader sequence by interfering with the selective binding of an essential Iron Regulatory Protein, IRP-1, to the functional RNA enhancer in front of the -Synuclein messenger.
The 3' leader sequence of NV-B is identical in length to those of all other paramyxoviruses and has nucleotide changes at positions 14 and 47 compared to NV-M.
In the Access assay, immunoactivity was markedly decreased if a leader sequence was present in the TnI molecule.
patent 5,166,195, covers phosphorothiate oligonucleotide compositions designed to selectively bind to RNA encoding the HIV tat protein, blocking replication of the virus and the 5' leader sequence, which is common to all HIV RNA transcripts.
The International Engineering Consortium (IEC) presented its prestigious 2009 DesignVision Award to Design For Power[TM] (DFP) leader Sequence Design for its breakthrough PowerArtist low-power design tool.