DURECT's Epigenomic Regulator Program includes the lead molecule
DUR-928 in Phase 1 development.
Dezima s lead molecule
is the cholesterol-lowering drug TA-8995.
Identification of the lead molecule
is currently in progress.
pro] inhibitors may be useful for SARS therapy, but results of recent in vitro testing of the lead molecule
, AG7088, were negative (3).
The company's first Phase I clinical trial for its lead molecule
, trans sodium crocetinate, shows the drug is well-tolerated in healthy human subjects at doses significantly higher than the estimated efficacious human dose.
Under the agreement, Diosynth Biotechnology will support the process improvement, process development and clinical product manufacturing for the lead molecule
TRIN 2755, the company's lead molecule
in a series of novel triazene analogs, exerts rapid metabolic clearance while, at the same time, showing very good tolerability in early toxicology studies.
Glenmark has selected a lead molecule
named GRC 17536 which is currently finishing up Phase 1 enabling GLP studies.
Given the recently achieved synthesis of sceptrin in multi-gram quantities by the Baran laboratory, sceptrin could prove to be an attractive lead molecule
for further preclinical testing and development for therapeutic purposes," said Dr.
INDIANAPOLIS & HYDERABAD, India -- Dow AgroSciences LLC, a wholly owned subsidiary of The Dow Chemical Company (NYSE: DOW), announced today that the company has identified a new lead molecule
for advancement in its alliance with GVK Biosciences (GVK BIO), Asia's leading Contract Research Organization.
Naurex's lead molecule
, GLYX-13, has demonstrated rapid, robust, and sustained efficacy in multiple Phase 2 clinical studies in depression, an area of high unmet need that has seen little innovation in decades.
The lead molecule
, HM30181A, has been shown in clinical studies to enhance the absorption of anticancer drugs including paclitaxel and irinotecan into orally available drugs.