Findings from a prospective, observational study suggest that being large for gestational age
is a marker for fetal hyperinsulinemia in an environment of either gestational diabetes or maternal obesity, and possibly glucose intolerance, supporting "the hypothesis that abnormal fetal nutrition predisposes to insulin resistance in later life," said Dr.
Keywords: Growth percentiles, Small for gestational age, Large for gestational age
, Birth weight, Neonate.
Thirteen infants (37%) were found to be large for gestational age
As such, the pregnancy with impaired fetal growth, resulting in small for gestational age (SGA) neonates, should have an increased placental weight to birth weight ratio (placental ratio) compared to those with appropriate for gestational age (AGA) or large for gestational age
(LGA) infants; but studies have shown that this is not true (9).
Women with the highest TG levels also were more likely to have infants classified as large for gestational age
These outcomes were rate of cesarean sections, admissions to the neonatal intensive care unit, infants born large for gestational age
(above the 90th percentile), and macrosomia (birth weight more than 4,000 g) (see chart).
Outcomes of interest included newborn birth weight, birth weight z score, Ponderal Index, and large for gestational age
(LGA; defined as greater than the 90th percentile).
The most striking safety signal is a consistent, 50% increased rate of babies born following vitrification who are large for gestational age
445 g; 13% were macrosomic and 38% were large for gestational age
19), maternal obesity alone increased the frequency of large for gestational age
(LGA) by a factor of 1.
75 odds ratio above the mean for large for gestational age
(LGA), neonatal body fat greater than 90th percentile, and cord blood hyperinsulinemia.
13%) or the incidence of infants that were large for gestational age