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lapatinib

   Also found in: Wikipedia 0.01 sec.
lapatinib,
a miscellaneous antineoplastic.
indication This drug is used to treat advanced breast cancer in patients with tumors that overexpress HER2 protein and who have received previous chemotheraphy.
contraindications Pregnancy, breastfeeding, torsade de points, and known hypersensitivity to this drug prohibit its use.
adverse effects Adverse effects of this drug include fatigue, insomnia, palpitations, anorexia, diarrhea, dyspepsia, mouth ulcerations, nausea, vomiting, xerosis, rash, palmar-plantar erythrodysesthesia, and dyspnea. Life-threatening side effects include heart failure, QT prolongation, anemia, neutropenia, and thrombocytopenia.


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Tyrosine kinase inhibitors Lapatinib is a tyrosine kinase inhibitor (TKI) that competes with ATP for the kinase binding domain within the HER2 molecule thus inhibiting its downstream effects.
Lapatinib: The lapatinib package insert warns that decreases in LVEF have been reported with use of the drug and that normal LVEF should be confirmed prior to the start of treatment.
I've just had my first week of taking Lapatinib, it was good to get started at last.
 
 
 
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