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lanthanum carbonate |
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lanthanum carbonate Fosrenol Pharmacologic class: Phosphate binder Therapeutic class: Renal and genitourinary agent Pregnancy risk category C ActionDissociates in acidic environment of upper GI tract to release lanthanum ions, which bind dietary phosphate released from food during digestion and inhibit phosphate absorption by forming highly insoluble lanthanum phosphate complexes AvailabilityTablets (chewable): 250 mg, 500 mg ⊘Indications and dosages ➣ To reduce serum phosphate level in patients with end-stage renal disease Adults: Initially, 750 to 1,500 mg P.O. (chewed) daily in divided doses with meals; titrate every 2 to 3 weeks until serum phosphate falls to acceptable level. ContraindicationsNone PrecautionsUse cautiously in: Administration• Give before meals; ensure that patient chews tablets completely before swallowing.
Adverse reactionsCNS: headache CV: hypotension GI: nausea, vomiting, diarrhea, constipation, abdominal pain Metabolic: hypercalcemia Respiratory: bronchitis, rhinitis Other: dialysis graft complication or occlusion InteractionsDrug-diagnostic tests. Serum calcium: increased Patient monitoring• Monitor serum calcium and phosphorus levels periodically. Patient teaching• Instruct patient to take drug with or immediately after meals and to chew tablets completely before swallowing. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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Because of their inherent molecular composition, versions "B" and "H" afford significantly higher acid binding and phosphate binding capacity than the benchmark drug lanthanum carbonate tetra hydrate ("LCTH"). New in vitro (laboratory) testing by Altair, has shown that RenaZorb "B" and "H" inherently carry a much larger capacity to neutralize stomach acid, potentially affording stomach pH values significantly higher than those reached with lanthanum carbonate tetra hydrate, the benchmark material and RenaZorb "A". The calculated dosage for RenaZorb is also lower than that proposed for lanthanum carbonate tetra hydrate, a new drug that has been submitted to the FDA for approval. |
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