lactam


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Related to lactam: lactone

lac·tam

, lactim (lak'tam, lak'tim),
Contractions of "lactoneamine" and "lactoneimine," and applied to the tautomeric forms -NH-CO- and -N=C(OH)-, respectively, observed in many purines, pyrimidines, and other substances; the latter form accounts for the acidic properties of uric acid.

lactam

/lac·tam/ (lak´tam) a cyclic amide formed from aminocarboxylic acids by elimination of water; lactams are isomeric with lactims, which are enol forms of lactams.
β-lactam  see under antibiotic.

lactam

[lak′təm]
a cyclic amide created by the elimination of a molecule of water from aminocarboxylic acid. Lactim is the isomeric form of lactam.

lac·tam

, lactim (lak'tam, -tim)
Contractions of "lactoneamine" and "lactoneimine," applied to the tautomeric forms -NH-CO- and -N=C(OH)-, respectively, observed in many purines, pyrimidines, and other substances.

lactam

a cyclic amide formed from aminocarboxylic acids by elimination of water; lactams are isomeric with lactims, which are enol forms of lactams.

β-lactam antibiotics
includes the penicillins, cephalosporins, carbapenems and penems. See also β-lactam ring (below).
β-lactam ring
an integral part of the formula of β-lactam antibiotics. Disruption of the ring by β-lactamase produced by some bacteria, e.g. Escherichia coli, Bacillus anthracis, destroys the antimicrobial activity of the compound.
References in periodicals archive ?
The antibiotics investigated in the study included penicillins (ampicillin, carbenicillin and piperacillin), 1st generation cephalosporins (cephalothin), 2nd generation cephalosporins (cefuroxime, cefoxitin and cefaclor), 3rd generation cephalosporins (ceftriaxone, cefotaxime and ceftazidime), 4th generation cephalosporins (cefepime) carbapenems (imipenem) and monocyclic lactams (aztreonam).
Mitim's product portfolio includes beta lactams in dry sterile powder for injectable solutions, tablets and oral suspensions.
This proportion was referred as presumably false positive proportion since no confirmatory quantitative method was applied and therefore it was impossible to ascertain true if any concentration of [beta] lactam residues in these samples.
Comparative in vitro activity of beta lactam / beta lactamases inhibitor combinations against gram negative bacteria.
Department of Energy Joint BioEnergy Institute researchers demonstrated production of the lactam precursors using an enzymeacyl-CoA ligasefrom Streptomyces aizunensis.
A blend of a hydrophobic additive and a nylon polymer includes a nylon other than a copolymer formed front a cyclic lactam and a C6-10 diamine monomer or a C6-10 diacid monomer.
Effectiveness of beta lactam antibiotics compared with antibiotics active against atypical pathogens in non-severe community acquired pneumonia: meta-analysis.
The transaction also cements our leading position in beta lactam production and provides Recipharm not only with additional scale but also opportunities to realise commercial and operational synergies as we combine it with our existing Italian business".
Mitim is currently owned by a private Italian family and is specialised in the filling of injectable beta lactam products.
The results of this work indicated that beta lactams evaluated may delay the maturation of somatic embryos of the calli, or the course from globular stage to bipolar shoots.
At present the assay is useful for qualitative determination of the presence of lactams and quantitation of samples known to contain only amoxicillin.
INDEX TERMS: Pseudomonas aeruginosa, anti-Pseudomonas antibiotics, Beta Lactams.