kynurenine


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kynurenine

 [kin″u-re´nin]
a metabolite of tryptophan found in microorganisms and in the urine of normal animals; it is a precursor of kynurenic acid and an intermediate in the conversion of tryptophan to niacin.

ky·nu·ren·ine

(kī'nū-ren'in),
A product of the metabolism of l-tryptophan, excreted in the urine in small amounts; elevated in cases of vitamin B6 deficiency.

kynurenine

/kyn·ure·nine/ (kin″u-rĕ´nēn) an aromatic amino acid, first isolated from dog urine; it is an intermediate in the catabolism of tryptophan.

ky·nu·ren·ine

(kin-yūr'ĕ-nēn)
A product of the metabolism of l-tryptophan, excreted in the urine.

kynurenine

a metabolite of tryptophan found in microorganisms and in the urine of normal animals; it is a precursor of kynurenic acid and an intermediate in the conversion of tryptophan to niacin.
References in periodicals archive ?
Kyn said the first programme focuses on "Kynase," an enzyme that degrades kynurenine directly and thereby addresses both IDO- and/or TDO-driven immunosuppression.
Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme that catabolizes tryptophan into a stable metabolite under the kynurenine pathway.
Therefore there is a need that effects of DS on kynurenine pathway should be further investigated to rule out the protective effect of DS in inflammation-induced depression and Alzheimer disease.
Rescue of white egg 1 mutant by introduction of the wild-type Bombyx kynurenine 3-monooxygenase gene.
It was reported on Friday that the collaboration is aimed at novel small molecule modulators of the kynurenine pathway as therapies for metabolic disorders and age-related diseases.
IDO and TDO are enzymes expressed by many tumor cells and cells in the surrounding microenvironment that suppress T-cell function by producing a potent immunosuppressive factor, kynurenine, thus inhibiting the immune system from identifying and destroying certain types of tumors.
605 Kynurenine 3-monooxygenase L-Kynurenine (L-Kyn) (kynurenine hydroxylation 3-hydroxylase) -0.
Attention-deficit hyperactivity disorder (ADHD) and glial integrity: An exploration of associations of cytokines and kynurenine metabolites with symptoms and attention.
Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection.
The study showed that exercise training induces changes in skeletal muscle that can rid the blood of kynurenine, which accumulates during stress and is harmful to the brain.
Thus, instead of serotonin production, tryptophan is diverted to the synthesis of the NMDA-receptor agonists kynurenine and quinolinic acid, which leads to apoptosis.