kynurenine


Also found in: Encyclopedia, Wikipedia.

kynurenine

 [kin″u-re´nin]
a metabolite of tryptophan found in microorganisms and in the urine of normal animals; it is a precursor of kynurenic acid and an intermediate in the conversion of tryptophan to niacin.

ky·nu·ren·ine

(kī'nū-ren'in),
A product of the metabolism of l-tryptophan, excreted in the urine in small amounts; elevated in cases of vitamin B6 deficiency.

kynurenine

/kyn·ure·nine/ (kin″u-rĕ´nēn) an aromatic amino acid, first isolated from dog urine; it is an intermediate in the catabolism of tryptophan.

ky·nu·ren·ine

(kin-yūr'ĕ-nēn)
A product of the metabolism of l-tryptophan, excreted in the urine.

kynurenine

a metabolite of tryptophan found in microorganisms and in the urine of normal animals; it is a precursor of kynurenic acid and an intermediate in the conversion of tryptophan to niacin.
References in periodicals archive ?
TES Pharma and EPFL announce a new research and development collaboration on novel small molecule modulators of the kynurenine pathway as therapies for metabolic disorders and age-related diseases.
605 Kynurenine 3-monooxygenase L-Kynurenine (L-Kyn) (kynurenine hydroxylation 3-hydroxylase) -0.
Expression of these rate-limiting genes leads to both depletion of Trp and accumulation of the Trp breakdown product kynurenine (Kyn) in the tumour microenvironment.
That result "suggests kynurenine may be a much more malignant molecule than we had previously appreciated," Miller says.
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.
69-fold), whereas the downstream metabolite kynurenine was significantly increased (2.
1964), is attributable to inhibition of kynurenine formamidase activity and nicotinamide adenine dinucleotide biosynthesis (Seifert and Casida 1980) (see Supplemental Material, Figure 10B).
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Of the dietary tryptophan (Trp) that is not used for protein biosynthesis, the majority is catabolised along the quinolinic branch of the kynurenine (Kyn) pathway to provide [NAD.
Glycine also assists in the regulation of glutamate NMDA receptors and decreases the neurotoxic effects of kynurenine, released during stress.
SANTIAGO, CHILE -- A Th1/Th2 immune imbalance affecting kynurenine metabolism may play a significant role in the pathogenesis of schizophrenia, Dr.
Niacin is obtained in 2 different ways: it can be absorbed as preformed nicotinic acid or amide from the diet or synthesised in the liver from tryptophan (provitamin) via the kynurenine pathway.