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kuru

   Also found in: Dictionary/thesaurus, Wikipedia, Hutchinson 0.03 sec.
kuru /ku·ru/ (koo´roo) an infectious form of prion disease with a long incubation period found only in New Guinea and thought to be associated with ritual cannibalism.
ku·ru (kr)
n.
A progressive, fatal spongiform encephalopathy, probably caused by a slow-acting virus, that is endemic to certain peoples of New Guinea and may be transmitted through cannibalism.

kuru
[ko̅o̅′ro̅o̅]
Etymology: New Guinea, trembling with fear
a slow, progressive, fatal infection of the central nervous system that was endemic to natives of the New Guinea highlands. The incubation period could be 30 or more years, but death usually occurred within months of the onset of symptoms. It was characterized by ataxia and decreased coordination progressing to paralysis, dementia, slurring of speech, and visual disturbances. Disease was transmitted by ritual cannibalism of brain tissue during funeral rites. No new cases have been recorded since cessation of the cannibalism. This disease is a model for prion diseases such as BSE and variant CJD.

kuru
a chronic, progressive, uniformly fatal central nervous system prion disease of humans probably resembling the scrapie agent of sheep, and transmissible to nonhuman primates; seen only in the Fore and neighboring peoples of New Guinea. Believed to be transmitted by cannibalism.


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Outbreaks of prion disease include an epidemic of kuru among the cannibalistic Fore tribe of the New Guinea highlands (9) and an epizootic of BSE in the United Kingdom, caused by feeding to cattle protein supplements derived from prion-infected cattle offal (10).
Scientists have discovered that the condition, called fatal familial insomnia, arises from a genetic mutation that creates prions, the same kind of misshapen proteins that cause scrapie, mad cow disease, kuru, and Creutzfeldt-Jakob disease.
It is a prion disease requiring a protein component (prion) for transmissibility, similar to kuru, bovine spongiform encephalopathy (mad cow disease), and scrapie.
 
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