The histology of flat condylomas shows acanthotic epithelium with mildly attenuated rete pegs, dyskeratosis, and koilocytotic atypia
in superficial cells.
In 2001, the Bethesda system (TBS) encompassed HPV infection known as koilocytotic atypia
and mild dysplasia/cervical intraepithelial neoplasia 1 as low-grade squamous intraepithelial lesion (LSIL) (8)
Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 1 (LSIL/CIN 1) is characterized by koilocytotic atypia
, nuclear enlargement, hyperchromasia, and perinuclear cytoplasmic clearing.
Koilocytotic atypia defined by Koss and Durfee (1956) and associated with HPV infection by Meisels and Fortin (1976) has been the most reliable indicative of cytomorphological lesions related to HPV (Yamamoto et al.
Cytological and pathologic study of koilocytotic atypia.
In peri- and post-menopausal women, squamous atypia are often mistakenly classified as koilocytotic atypia
but when evaluated by polymerase-chain-reaction analysis, these findings have been shown not to be associated with the human papillomavirus (HPV).
Unusual patterns of squamous epithelium of the uterine cervix and pathologic study of koilocytotic atypia
The endocervical margins were normal and free of disease, but minor koilocytotic atypia
cytolgic changes were noted along the ectocervical margin.
Previously, evidence of a human papillomarvirus (HPV) infection without dysplasia was reported as koilocytotic atypia
Under the Bethesda System, women with koilocytotic atypia
would be reclassified as having SIL.
Dagger])Cellular changes of human papillomavirus (HPV)-- previously termed koi locytosis, koilocytotic atypia
, or condylomatous atypia--are included in the category of low grade squamous intraepithelial lesio n.
No significant association was detected between Papanicolaou smear classification and the presence of C trachomatis despite a relatively high rate of koilocytotic atypia