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knockout mouse

   Also found in: Wikipedia 0.03 sec.
knock·out mouse (nkout)
n.
A transgenic mouse that has been genetically engineered to exhibit mutations in specific genes.
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Using targeted mutations in transgenic mice, scientists began to develop knockout mouse models of human disease to test the role of specific genes in disease etiology and progression (Eddy 1993; Smithies and Kim 1994).
Of mice and molecules: research with genetically modified mouse models by Shostak, Sara / Environmental Health Perspectives
Hannon explains that creating a knockout mouse can take well over a year, while knocking down a gene with RNAi takes only a few days.
Sound off: with RNA interference, gene silencing roars into labs by Brownlee, Christen / Science News
VelociGene uses a proprietary process to create genetic modifications in a mouse in a precise and high-throughput manner and was recently selected by the National Institutes of Health for use in its Knockout Mouse Project.
AstraZeneca Licenses Regeneron's VelocImmune(R) Technology for ... by Business Wire
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