knock·out mouse (n k out )n. A transgenic mouse that has been genetically engineered to exhibit mutations in specific genes. |
knockout mouse,
a mouse that has had a specific gene artificially deleted from its genome.
Knockout Mouse
A genetically engineered mouse created by gene targeting—targeted gene disruption—in which a specific gene is deleted or inactivated by homologous recombination, to study the effects of its absence. Knockout mouse models of human disease have been created for atherosclerosis, cancer, cystic fibrosis, etc.
mouse [mows]
a small rodent, various species of which are used in laboratory experiments.
1. a small loose body.
2. a computer pointing device.
joint mouse a movable fragment of synovial membrane, cartilage, or other body within a joint; usually associated with degenerative osteoarthritis and osteochondritis dissecans.
knockout mouse a mouse that has had a specific gene artificially deleted from its genome.
nude mouse a mouse homozygous for the nu gene; these mice are hairless, lack a thymus, and thus lack T lymphocytes.
peritoneal mouse a free body in the peritoneal cavity, probably a small detached mass or omentum, sometimes visible radiographically.
SCID mouse (severe combined immunodeficiency) a strain of mice lacking in T and B lymphocytes and immunoglobulins, either from inbreeding with an autosomal recessive trait or from genetic engineering, used as a model for studies of the immune system.
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