kininogen


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kininogen

 [ki-nin´o-jen″]
either of two plasma α2-globulins that are kinin precursors. High-molecular-weight (HMW) kininogen (also called Fitzgerald factor) is split by plasma kallikrein to produce bradykinin; low-molecular-weight (LMW) kininogen is split by tissue kallikrein to produce kallidin. Deficiency of HMW kallikrein is a rare condition but may be considered when prolonged activated partial thromboplastin time cannot be explained by deficiencies of other more common factors.

ki·nin·o·gen

(ki-nin'ō-jen'),
The globulin precursor of a plasma kinin.

kininogen

/ki·nin·o·gen/ (ki-nin´o-jen) either of two plasma α2-globulins that are kinin precursors, HMW (high-molecular-weight) k., precursor to bradykinin, and LMW (low-molecular-weight) k., precursor to kallidin.

ki·nin·o·gen

(ki-ninō-jen)
The globulin precursor of a (plasma) kinin.

kininogen

an α2-globulin of plasma that is a precursor of the kinins.
References in periodicals archive ?
Schweitzer and Cartee (40) demonstrated that normal rats deficient in kininogen did not present differences in glucose transport after exercise.
In affected patients, "activation of the kallikreinkinin cascade leads to uncontrolled generation of plasma kallikrein and consequent proteolysis of high-molecular-weight kininogen.
Intravenous bromelain administration in rats markedly reduced plasma prekallikrein and high molecular weight kininogen 15 minutes after the injection, and the effect lasted for 72 hours.
factor XII, low molecular weight kininogen, and prekallikrein) are activated and these factors support (at least in part) thrombin generation.
And PCR showed the amplification of genes: Membrane metalloendopeptidase (MME), sucrase-isomaltase (SI), butyrylcholinesterase (BCHE), and kininogen (KNG).
Kinins derived from kininogen produced by tissue kallikrein (TK) exert a broad spectrum of cellular functions via activation of the bradykinin B1 or B2 receptor (B1R or B2R, resp.
8-9) Consequently, the contact pathway, constituted by FXII, prekallikrein, and high-molecular-weight kininogen, is consequently incomplete in birds.
It is affected by a decrease in plasma level of the coagulation factor(s) involved in intrinsic (XII, XI, IX, VIII, high molecular weight kininogen, and prekallikrein) and common (I, II, V and X) pathways.
s polyclonal antibodies include Plasminogen, Prothrombin, ATIII, PAI-1, Kininogen, Protein C, Protein S, Vimentin and Alpha 2- Macroglobulin.
Kinin (bradykinin) is one of the most potent endogenous pain inducing nonapeptide, and it is continuously generated at sites of infection and cancer tissues by kallikrein and other proteases, from kininogen.
DPK-060 is a new anti-microbial peptide which is structurally derived from the endogenous human protein kininogen.