kininogen


Also found in: Wikipedia.

kininogen

 [ki-nin´o-jen″]
either of two plasma α2-globulins that are kinin precursors. High-molecular-weight (HMW) kininogen (also called Fitzgerald factor) is split by plasma kallikrein to produce bradykinin; low-molecular-weight (LMW) kininogen is split by tissue kallikrein to produce kallidin. Deficiency of HMW kallikrein is a rare condition but may be considered when prolonged activated partial thromboplastin time cannot be explained by deficiencies of other more common factors.

ki·nin·o·gen

(ki-nin'ō-jen'),
The globulin precursor of a plasma kinin.

kininogen

/ki·nin·o·gen/ (ki-nin´o-jen) either of two plasma α2-globulins that are kinin precursors, HMW (high-molecular-weight) k., precursor to bradykinin, and LMW (low-molecular-weight) k., precursor to kallidin.

ki·nin·o·gen

(ki-ninō-jen)
The globulin precursor of a (plasma) kinin.

kininogen

an α2-globulin of plasma that is a precursor of the kinins.
References in periodicals archive ?
s polyclonal antibodies include Plasminogen, Prothrombin, ATIII, PAI-1, Kininogen, Protein C, Protein S, Vimentin and Alpha 2- Macroglobulin.
C1-INH regulates the actions of kallikrein, which cleaves high molecular-weight kininogen to generate bradykinin.
Plasma levels of factor XII, prekallikrein and high molecular weight kininogen in normal blood donors and patients having suffered venous thrombosis.
As discussed earlier, IHC can useful, with the potential for also using p63 and high molecular weight kininogen immunostains that, in contrast to urothelial lesions, are negative in NA.
Factor V, VIII, X, XIII, Protein S, Kininogen, Plasminogen, Prothrombin, Fibrinogen.
This test primarily monitors deficiencies in factors VIII, IX, XI, XII, prekallikrein and high molecular weight kininogen (HMWK).
This postulate is supported by kallikrein action on kininogen precursors to generate bradykinin, which enhance microvascular permeability(3).
PRCP converts PK to plasma kallikrein when the high molecular weight kininogen (HK) combines with PK, forming the HK-PK complex that binds to human umbilical vein endothelial cells (HUVEC) membranes.
5) The antibody does not react with high molecular weight kininogen.
Factor XII, high-molecular-weight kininogen, and prekallikrein are known as contact factors.
The venom enzyme, without an exogenous source of kininogen, did not cause an increase in capillary permeability as determined by the Evans blue stain method.
Ecallantide produces rapid, specific, and reversible blockade of plasma kallikrein, by inhibiting the plasma kallikrein-mediated cleavage of high-molecular weight kininogen (HMWK), directly affecting the pathways involved in both the upstream mediators of bradykinin production as well as the downstream mediators of degradation, thus preventing the release of bradykinin.