kinase


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kinase

 [ki´nās]
1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor, and named, according to the acceptor, as creatine kinase, fructokinase, etc.
2. an enzyme that activates a zymogen, named, according to its source, such as enterokinase, streptokinase, etc.

ki·nase

(kī'nās),
1. Enzyme that catalyzes conversion of a proenzyme to an active one (for example, enteropeptidase [enterokinase]). Important in salvage and recycling of nucleotides. Some antiviral agents work by inactivating viral or tumor kinases
2. Suffix attached to some enzymes to indicate transformation.

kinase

/ki·nase/ (ki´nās)
1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor.
2. a suffix used in the names of some enzymes that convert an inactive or precursor form.

kinase

(kī′nās′, -nāz′, kĭn′ās′, -āz′)
n.
Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor protein. Kinases regulate many essential cellular processes.

kinase

[kī′nās]
Etymology: Gk, kinesis, motion; ase, enzyme
1 an enzyme that catalyzes the transfer of a phosphate group or another high-energy molecular group to an acceptor molecule. Each of these kinases is named for its receptor, such as acetate kinase, fructokinase, or hexokinase.
2 an enzyme that activates a preenzyme (zymogen). Each of these kinases is named for its source, such as bacterial kinase, enterokinase, fibrinokinase, insulin kinase, staphylokinase, streptokinase, streptokinase-streptodornase, or urokinase.

ki·nase

(kī'nās)
1. An enzyme catalyzing the conversion of a proenzyme to an active enzyme.
2. An enzyme catalyzing the transfer of phosphate groups to form triphosphates (e.g., adenosine triphosphate).

kinase

See TRANSFERASE.

kinase

an enzyme that catalyses the transfer of a phosphoryl group from ATP to another compound.

kinase

enzyme catalysing conversion of a proenzyme to an active enzyme; e.g. adenosine triphosphate (ATP) protein kinase (catalyses formation of ATP from adenosine diphosphate)

kinase

1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor, and named, according to the acceptor, as creatine kinase, fructokinase, etc.
2. an enzyme that activates a zymogen, and named, according to its source, as enterokinase, streptokinase, etc.

protein k's
cellular enzymes which utilize ATP to phosphorylate proteins, usually at a selected OH group of serine, threonine or tyrosine residue in the protein, so as to increase or decrease the activity of the protein.
protein kinase C
membrane bound protein kinase designated C because it requires Ca2+ and phosphatidyl serine for its activity. Activated by sn-1,2-diacylglycerol (DAG) produced from phosphatidyl inositol 4,5-bisphosphate. Phosphorylates target proteins such as the insulin receptor, β-adrenergic receptor, glucose transporter, HMG-CoA reductase, cytochrome P-450 and tyrosine hydroxylase.
References in periodicals archive ?
To support kinase biology, Promega has just launched more than 100 individual full-length kinase target engagement assays.
To validate the docking protocol, the ligands from the complexed structures of PIM-1 and PIM-2 were extracted and redocked in the crystal structure of PIM-1 kinase (PDB code 3JYA) and PIM-2 kinase (PDB code 2IWI) bound with the inhibitor molecule.
Enhancedemphasis of pharmaceutical companies on R&D to come up with potential kinase inhibitors for treatment of cancers.
Summary: TEHRAN (FNA)- Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene.
Anderson, who also is a member of the University of Iowa Heart and Vascular Center, said: "The study showed, surprisingly, the importance of CaM kinase's effect on two particular amino acid targets among the thousands of amino acids that make up protein targets for phosphorylation by CaM kinase.
The role of rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.
Kinexus is poised to become a major proteomics and bioinformatics player with its focus on protein kinases and other cell signalling proteins for diagnostic and therapeutic applications.
P38 MAP kinase stimulates the proinflammatory factors tumor necrosis factor-[alpha], interleukin-1, and cyclooxygenase-2.
A novel putative tyrosine kinase receptor encoded by the eph gene.
Exposure to R5 gp120 and X4 gp 120 resulted in activation of pro line-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase related to focal adhesion kinase.
The oral drug, also known as STI-571, works by binding to Bcr-Abl tyrosine kinase on CML cells, thereby disabling them.