keratolytics

keratolytics

topical agents that break down keratin (by breaking intermolecular bonds and causing maceration); assist removal of tough, outer stratum corneum, and penetration of keratolytic or caustic medicaments to deeper tissues, e.g. 10+% salicylic acid (see caustics; and Table 1, Table 2)
Table 1: Keratolytic and caustic agents
Keratolytic/caustic agentIndicated use
Whitfield's ointment (3% salicylic acid and 6% benzoic acid in white soft paraffin)Treatment of mild tinea pedis
5% salicylic acid ointmentApplied daily for 7 days to soften hyperkeratosis and facilitate its removal
12% salicylic acid in collodionMacerating agent; painted over callosity and left in situ for 7 days, to assist removal of heavy callosity
20-40% salicylic acid plasterApplied topically and left in situ for 1-2 days to aid removal of corns
40-70% salicylic acid ointmentApplied topically in a cavitied pad and left in situ for 7 days for verruca treatment; the lesion should be masked
Calmurid cream (10% urea)To hydrate anhidrotic skin; applied daily to treat dyskeratosis
40% urea creamA strongly keratolytic agent, applied under an occlusive dressing and left in situ for 7 days, to soften, macerate and aid the reduction and removal of hypertrophied nails in patients who are unsuitable for nail avulsion
Monochloroacetic acidA deeply penetrating caustic that is painful in use Applied, retained in situ and reviewed within 3-7 days, for the treatment of verrucae:
1. as a saturated solution to the lesion
2. as a tiny crystal strapped over a masked lesion
3. as a tiny crystal embedded in 40-70% salicylic acid retained by a cavitied pad
Trichloroacetic acidA self-limiting caustic with a superficial action
Applied directly to the verruca, after initial scalpel debridement of the lesion
May be used in conjunction with 75-95% silver nitrate (see below) as a diagnostic or a final treatment of verrucae
75-95% Silver nitrateA self-limiting caustic with a superficial action, causing a dark brown discoloration of the skin to which it is applied; it is used for the treatment of shallow or mosaic verrucae.
Note: Some patients show an idiosyncratic local sensitivity or inflammatory reaction to applied silver nitrate
1. Applied directly to the lesion, after overlying callosity has been debrided off
2. Applied directly to the lesion in alternating layers with trichloroacetic acid
3. As a diagnostic aid to identify verrucous tissue; viral-infected skin cells show up as bright white dots within a few moments of the application of the layers of silver nitrate and trichloroacetic acid
Potassium hydroxide (KOH)A powerful keratolytic caustic with a great affinity for water that penetrates deeply dissolving precipitated protein; used to destroy soft tissues
1. Overlying hyperkeratosis is debrided off the verruca and the foot is immersed in water for 5 minutes to hydrate the skin, then dried; a KOH pellet is rubbed into the lesion; the foot is reimmersed in water and the jelly-like material formed by the KOH on the lesion surface is debrided off. The process is repeated once or twice until the lesion appears to have gone, then glacial acetic acid is applied to neutralize the KOH
2. A similar protocol may be used to ablate nail matrix after removal of the overlying section of nail plate
3. KOH 5% liquid applied to heavy callosity and left in situ for 5 minutes softens heavy callosity to ease its removal
Pyrogallol (pyrogallic acid)A powerful analgesic, non-self-limiting, caustic reducing agent. It may be used in the treatment of recalcitrant verrucae or neurovascular corns in areas of skin overlying a healthy layer of fibrofatty padding. It should only be used with great caution as its action continues after application has ceased and can lead to severe tissue breakdown that is slow to heal. It is incompatible with alkalis, iron salts, oxidizing agents and ammonium salts
1. 20% pyrogallol ointment for the treatment of neurovascular corns
2. 40% pyrogallol ointment for the treatment of VP
3. WP ointment (20% pyrogallol, 20% wheat germ oil) for the treatment of tough, fibrous, hyperkeratotic plantar lesions
PhenolAn analgesic, corrosive caustic. It is used as an 80% solution (liquefied phenol) to destroy soft-tissue lesions such as VP, or nail matrices (three applications, each of 1 minute duration). Its action is quenched by dilution with IMS or isopropyl alcohol. Healing is delayed for several weeks after its application
Glacial acetic acidA weakly acidic mild caustic that is crystalline at 14°C
1. As a paint to hard or vascular corns, or VP (return period 14-21 days)
2. As a paint to VP, alternating with silver nitrate 75% (in a similar manner to trichloroacetic acid)
3. To neutralize KOH (see above: KOH, point 1)
Nitric acidA powerful analgesic oxidizing caustic agent with a superficial action that offers a 'one-off' VP treatment
1. Applied to VP with a glass rod and left in situ for 5 minutes, followed by phenol solution 10%; the skin stains bright yellow
2. The lesion is saturated with phenol solution 5% for 5 minutes, then with nitric acid for 20-30 seconds, then once again with phenol solution 5%
Strong iodine solution (iodine solution 10%; iodine fortis)A strong astringent and vesicant agent. It is incompatible with many topical medicaments, and can cause sensitivity reactions in some patients
1. to shrink nail tufts
2. to shrink hypergranulation tissue
FormaldehydeA strongly astringent and antiseptic agent used in the treatment of VPs (the skin surrounding the lesion should be protected with petroleum jelly; sensitivity is likely)
1. 10% formaldehyde in collodion, painted on daily
2. 36% formaldehyde solution, painted on daily
Thermal caustics
CryosurgeryThe topical application of liquid nitrogen (at -196°C) or nitrous oxide (at -88.5°C) to destroy small soft-tissue lesions; the cell cytoplasm must be reduced to and maintained at -24°C or lower for at least 1 minute, and repeated for two further freezing episodes between which the area has been allowed to thaw. Cryosurgery is more effective when any overlying hyperkeratosis is removed before freezing
HyfrecationTissue destruction by initial fulguration (outlining and superficial charring) of the lesion by the application of high-frequency electrical energy), then electrodesiccation (electrocautery) of the lesion by the release of electrical energy whilst the probe is inserted into the lesion
ElectrosurgeryTissue removal using high-frequency energy waves to incise through tissue

Note: Please also refer to the text entries for each listed agent.

IMS, industrial methylated spirit; VP, verrucae pedis.

Table 2: Factors that should be considered in the use of chemical cauterizing agents to destroy verrucae
FactorComment
Lesion siteSuperficial lesion, non-weight-bearing skin - use liquid caustics
20% salicylic acid in collodion
Trichloroacetic acid, saturated solution (+75% sliver nitrate)
Deeper lesion, weight-bearing skin, good fibrofatty padding - either liquid or solid caustics
Monochloroacetic acid, saturated solution
40-70% salicylic acid ointment
Number and size of lesionsLarge lesions: ointment-based caustics
40-70% salicylic acid ointment Smaller and satellite lesions: caustic solutions
Alternating layers of trichloroacetic acid, saturated solution and 75% silver nitrate
Skin textureSweaty or hyperhidrotic skin
Padding cannot be retained in situ
Fair skin or atopic individuals; atrophic or dry skin
Tend to overreact/undergo tissue breakdown, to applied caustics
CirculationReduced arterial supply (diabetes, atherosclerosis)
Caustics may cause ulceration or predispose to infection as healing response is depressed (use astringents or mild keratolytics)
Impaired venous or lymphatic drainage (oedematous tissues)
Avoid strong caustics (use astringent agents or mild keratolytics)
NeuropathyImpaired pain awareness (as in diabetic neuropathy)
Do not use caustics (use astringents or mild keratolytics)
AvailabilityStrong acids should not be used unless both practitioner and patient are available for emergency appointments
Caustics may not be treatment of choice if patient cannot return weekly for ongoing treatments (consider a 'one-off' treatment, e.g. cryotherapy)
Opt for self-applied milder, topical ongoing treatments, if in patient's best interests
AgeStrong caustics should be avoided in young patients with a low pain threshold
Caustics that require padding to be retained in situ between treatments may be contraindicated in patients who cannot keep foot dry (e.g. swimmers)
Previous treatmentsIt is pointless continuing with a treatment that has already proved to be ineffective, or has caused an adverse reaction
Single treatmentsVerrucae pedis do not often respond to a single treatment, but methods include:
• Cryotherapy (application of liquid nitrogen, optimally every 3 weeks; ice ball must extend beyond lesion edge; contraindicated in patients with peripheral vascular disease)
• Electrosurgery (peripheral tissues must also be removed in order to clear all virally infected cells; requires local anaesthesia; contraindicated in patients with peripheral vascular disease or those with an indwelling pacemaker)
Alternative treatmentsAlternative treatments may be indicated for cases that have not responded to other forms of treatment: many of these therapies have not been tested by formal research
Thuja tincture: painted on lesion once or twice a day
Kalanchoe leaves: fleshy leaves split open and fleshy pulp left in situ on lesion; changed every 24-48 hours
Tea tree oil: painted on lesion daily, and covered
Banana skin: small piece of banana skin cut to size of lesion and strapped in place, pith side against lesion; changed every 24-48 hours
References in periodicals archive ?
13] These skin reactions can be managed by the use of moisturizers, corticosteroids, and keratolytics (salicylic acid).
If treatment is desired, emollients, keratolytics such as topical retinoids, salicylic acid, lactic acid, and urea may be used.
Isotretinoin 10 mg daily along with topical emollients and keratolytics.
Topical therapies such as keratolytics, retinoids, vitamin D derivatives, 5-flurouracil ointment, imiquimod cream, diclofenac gel, dermabrasion, cryotherapy, photodynamic therapy, carbon dioxide laser, excision, and skin grafting have been used alone or in combination, whereas systemic retinoids are useful in generalized porokeratosis cases.
For mild hyperkeratosis, emollients and keratolytics like salicylic acid, urea, benzoic acid, propylene glycol may help along with comfortable footwear to reduce callosities and blistering.
Treatment options include topical therapy (emollients, keratolytics such as salicylic acid or 12% ammonium lactate lotion, retinoids, vitamin [D.
3] About 80% of patients in this study had topical treatments in the form of steroids, antibiotics, calcineurin inhibitors and keratolytics.
Among classical keratolytics, salicylic acid (2-5%) and resorcin are used with a low rate at the present time (3%).
Emol- lients and keratolytics were applied for her skin condition.
Expert recommendations for treating heel cracks include the use of keratolytics, emulsifying ointments, silver nitrate, and 10% glycerol in sorbolene cream, along with treatment of any underlying conditions.
The skin manifestations are usually treated topically with emollients, keratolytics including salicylic acid and urea.
Phototherapy, photochemotherapy and systemic immunosuppressive agents are good therapeutic options for chronic plaque psoriasis 3 resistant to topical emollients and keratolytics.