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Keratinocytes

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Keratinocytes
Cells found in the epidermis. The keratinocytes at the outer surface of the epidermis are dead and form a tough protective layer. The cells underneath divide to replenish the supply.
Mentioned in: Ichthyosis, Skin Grafting

keratinocytes
(krat´inōsīts´),
n.pl a cell of the living epidermis and certain oral epithelia that produces keratin in the process of differen-tiating into the dead and fully ke-ratinized cells of the stratum corneum.


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To dissect the underlying control mechanisms for this process, we established a keratinocyte/fibroblast co-culture system and subsequently demonstrated more than a 10-fold increase in collagenase expression in fibroblasts co-cultured with keratinocytes relative to that of control cells.
Hyaluronan (HA) is produced by keratinocytes in human skin organ culture, and degraded locally in epidermis by an unknown metabolic route.
Once introduced into the skin, the virus invades the keratinocytes and takes over the cells.
 
 
 
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