Dermatophytic fungi release proteolytic enzymes and keratinases
into the skin.
The purified keratinases known till now cannot completely solubilize native keratin, their exact nature and uniqueness for keratinolysis is still an enigma in the world of proteases (Ignatova et al,, 1999).
Keratinase assay and Optimization keratinase production
Biodegradation of feather waste by extracellular keratinases
and gelatinases from bacillus spp.
Establishment of infection by fungi depends on the host-cell interaction with complex interplay of secretion of virulence factors mainly proteinases including elastinases, keratinases
, gelatinases, lipases and phospholipases.
Similarities and specificities of fungal keratinolytic proteases: Comparison of keratinases
of Paecilomyces marquandii and Doratomyces microsporus to some known proteases.
The use of specific proteolytic enzymes (proteases), in particular under alkaline conditions, that have been shown to break-down the prion protein and reduce infectivity (for example, enzymes such as 'Prionzyme' and the class known as keratinases
, under specific conditions).
These fungi produce keratinases
and collageneases that provide nutrients to the fungi by digesting host tissues.
The basic pathophysiology of tinea infection is inoculation of keratinized skin by dermatophytic fungi followed by release of keratinases
and proteolytic enzymes.
Purification and partial characterization of two extracellular keratinases
of Scopulariopsis brevicaulis.
thermoviolaceus (3,5,14,15) and Keratinases
from bacteria are isolated and characterized.
KEY WORDS: Keratinophilic fungi, Keratinase
, Dermatophytosis, Domestic animals.