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keratan sulfate

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keratan sulfate /ker·a·tan sul·fate/ (ker´ah-tan) either of two glycosaminoglycans (I and II), consisting of repeating disaccharide units of N -acetylglucosamine and galactose, but differing slightly in carbohydrate content and localization. It occurs in cartilage, the cornea, and in the nucleus pulposus and is also an accumulation product in Morquio's syndrome.
ker·a·tan sulfate (kr-tn)
n.
Any of several mucopolysaccharides in cartilage, bone, connective tissue, and the cornea. Also called keratosulfate.

keratan sulfate [ker´ah-tan]
either of two sulfated mucopolysaccharides (I and II). Keratan sulfate is an important component of the proteoglycan of cartilage, and occurs in the cornea and the nucleus pulposus, and is also an accumulation product in Morquio's syndrome.

keratan sulfate
a glycosaminoglycan which exists as either of two sulfated mucopolysaccharides (I and II). Keratan sulfate is an important component of the proteoglycan of cartilage, and occurs in the cornea and the nucleus pulposus.


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A sampling of topics: gene expression profiling toward understanding of ALS pathogenesis, brain keratan sulfate and glial scar formation, molecular mechanisms of axon specification and neuronal disorders, and involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.
This macromolecule naturally co-exists with several other known GAGs, including keratan sulfate, heparin, heparan sulfate and dermatan sulfate.
 
 
 
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