1,8,9) It is characterized by villous endothelial karyorrhexis
with congestion, red blood cell extravasation, stromal apoptosis, and septation of the endothelial lumens (Figures 9 and 10).
They were observed for Nuclear abnormalities like Karyolysis (KL), Karyorrhexis
(KR), Binucleated egg (BN) under bright field Nikon microscope under 10 x 100 magnifications.
d) Photomicrograph of a section of liver (H & E; x100) from a mouse treated with acetaminophen shows extensive centrilobular necrosis, hydropic degeneration of hepatocytes, destruction of central vein endothelium, karyolysis, pyknosis, and karyorrhexis
On examination of the Hematoxylin and Eosin stained sections of the diabetic group, it revealed myocardial disarray accompanied with loss of the normal striated architecture of the cardiomyocytes with presence of characteristic degenerative changes of the nuclei in the form of pyknosis, karyorrhexis
, and karyolysis.
ONL nuclear deformations (arrows) were observed in (A) control ONL nucleus and as (B) nucleolus condensation, (C) karyolysis, (D, E pyknosis, and (F) karyorrhexis
The cellular variant is defined by identification of at least 1 glomerulus with endocapillary hypercellularity (including foam cells, macrophages and other leukocytes, and endothelial cells, occasionally associated with hyalinosis, karyorrhexis
, and fibrin) involving >25% of the glomerular tuft, leading to occlusion of the capillary lumen .
The nuclei of hepatocytes in such areas were pyknotic while other cells showed karyolisis or karyorrhexis
, as well as evident cytoplasmic fragmentation, all indicating severe coagulative necrosis.
Similarly, necrotic cell death has been reported accompanied by irreversible changes in the nucleus, such as karyolysis, pyknosis and karyorrhexis
(21) as well as the loss of structure and fragmentation of the cytoplasm, similar to what is observed at high magnification (Figure 2A3c) when compared with the nonischemic control (Figure 2A1a).
Ultimately, the nuclei fragments and breaks down, a process known as karyorrhexis
In the late stages of infection, karyorrhexis
and cellular disintegration may occur, leading to the formation of necrotic areas characterized by vacuolization (47), (49).
Small cell carcinoma usually shows smearing artefacts, nuclear molding, stippled chromatin with inconspicuous nucleoli, necrotic debris and karyorrhexis
Some of the hepatocytes around granuloma were shrunken, atrophy, fatty degeneration, pyknosis and karyorrhexis
was also visible.