kallikrein


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kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

kallikrein

/kal·li·kre·in/ (kal″ĭ-kre´in) any of several serine proteinases that cleave kininogens to form kinins.
plasma kallikrein  a plasma hydrolase that cleaves HMW kininogen to produce bradykinin and also activates blood coagulation factors XII and VII and plasminogen.
tissue kallikrein  a hydrolase of tissues and various glandular secretions that cleaves LMW kininogen to form kallidin.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.

kallikrein

(kal´ikrē´in),
n a group of enzymes (plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen to bradykinin or kallidin; trypsin and plasmin can also affect the conversion.
kallikrein-kinin system,
n a proposed hormonal system that functions within the kidney, with the en-zyme kallikrein in the re-nal cortex mediating production of bradykinin, which acts as a vasodilator peptide.

kallikrein

any of a group of proteolytic enzymes present in various glands, lymph, urine, blood plasma, etc., or produced directly from mast cells or basophils, or indirectly from activated platelets. The major action of kallikreins is the liberation of kinins from α-2-globulins (kininogens), and they hence have vasodilator and whealing actions.

kallikrein-kinin system
the enzyme system responsible for capillary permeability and smooth muscle contraction.
References in periodicals archive ?
PSA and hK2 are members of the kallikrein gene family (3), and their expression is regulated by the ligand-dependent activation of the androgen receptor.
HAE is caused by low or dysfunctional levels of C1 esterase inhibitor (C1-INH), a naturally occurring molecule that inhibits plasma kallikrein, a key mediator of inflammation, and other serine proteases in the blood.
Temporal variations of glandular kallikrein, protein and amylase in mixed human saliva.
Comparisons of this low response to the results obtained with equal concentrations of bradykinin and kallikrein show that the enzyme does not produce a hypotensive kallikrein-like response in the rabbit model.
Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue.
These findings suggest that hK7 may join other kallikrein members as a potential ovarian cancer biomarker.
Plasma kallikrein is a vascular serine protease which generates bradykinin, excessive production of which leads to edema in humans.
KalVista Pharmaceuticals ("KalVista"), an ophthalmology company with a focus on diabetic macular edema (DME), today announces that it has begun a Phase I, First in Human, trial of its novel plasma kallikrein inhibitor, KVD001, for the treatment of DME.
Transcription of the kallikrein genes is modulated by a large number of stimulatory and inhibitory substances, among which sex steroid hormones are the best characterized.
Cambridge, England) the right to offer OPKO's novel panel of kallikrein biomarkers and associated algorithm for the detection of prostate cancer in a laboratory setting in the U.
In addition, this project will provide KalVista with access to new ophthalmology projects and dovetails nicely with our internal programmes focused on intravitreal and oral plasma kallikrein inhibitors for DME.