juvenile myoclonic epilepsy type 1

juvenile myoclonic epilepsy type 1

A subtype of idiopathic generalised epilepsy (OMIM:254770) characterised by afebrile seizures of adolescent onset and myoclonic jerks that occur while awake, which are triggered by sleep deprivation and fatigue.

Molecular pathology
Defects in EFHC1, which encodes an EF-hand-domain protein thought to enhance calcium influx through CACNA1E, cause juvenile myoclonic epilepsy type 1.
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Thank you, sir," said Jerry, "but I have only taken out a six-days' license,* and therefore I could not take a fare on a Sunday; it would not be legal.
It is your respectability and humanity that licenses and protects his brutality.
Presently he said just what I was expecting he would say--that he had no license to carry passengers, and therefore was afraid the law would be after him in case the matter got noised about or any accident happened.
The forenoon of the next day was devoted to obtaining the license -- the personal distinction of making the declaration on oath being eagerly accepted by Noel Vanstone, who swore, in perfect good faith (on information previously obtained from the captain) that the lady was of age.
More potent intoxicants these than any that need licenses for their purveyance, responsible-- see the poets--for no end of human foolishness.
In this, I respectfully contend, I have in no respect exceeded the fair license due to the author of a fictitious composition.
The first request I made, after I had obtained my liberty, was, that I might have license to see Mildendo, the metropolis; which the emperor easily granted me, but with a special charge to do no hurt either to the inhabitants or their houses.
Some action had to be taken quickly, so licenses were given to four other manufacturers to make bells, switchboards, and so forth.
They so far exceed the usual though unjustifiable licenses of party artifice, that even in a disposition the most candid and tolerant, they must force the sentiments which favor an indulgent construction of the conduct of political adversaries to give place to a voluntary and unreserved indignation.
According to the former, letters of marque could be granted by the States after a declaration of war; according to the latter, these licenses must be obtained, as well during war as previous to its declaration, from the government of the United States.
The critics, therefore, are in error who censure these licenses of speech, and hold the author up to ridicule.
That it is true his other virtues would not have been sufficient for him may be proved by the case of Scipio, that most excellent man, not only of his own times but within the memory of man, against whom, nevertheless, his army rebelled in Spain; this arose from nothing but his too great forbearance, which gave his soldiers more license than is consistent with military discipline.

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