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ixabepilone

   Also found in: Wikipedia 0.01 sec.
ixabepilone,
a miscellaneous antineoplastic.
indication This drug is used to treat breast cancer.
contraindications Known hypersensitivity to drugs with polyoxyethylated castor oil, pregnancy, and breastfeeding prohibit the use of this drug.
adverse effects adverse effects of this drug include bradycardia, abnormal ECG, angina, atrial flutter, cardiomyopathy, chest pain, edema, MI, vasculitis, abdominal pain, anorexia, colitis, constipation, coagulopathy, gastritis, jaundice, gastroesophageal reflux disease, hepatic failure, infections, rash, hypokalemia, metabolic acidosis, impaired cognition, chills, fatigue, fever, flushing, headache, insomnia, bronchospasm, cough, dyspnea, and dehydration. Life-threatening side effects include neutropenia, thrombocytopenia, anemia, and anaphylaxis. Common side effects include hypotension, nausea, vomiting, diarrhea, alopecia, arthralgia, myalgia, peripheral neuropathy, and hypersensitivity reactions.


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Patients receiving capecitabine in combination with anthracyclines, taxanes, vinorelbine, or ixabepilone need to be monitored for bone marrow suppression.
A number of Phase II studies in MBC of ixabepilone as a single agent in patients refractory to anthracyclines, taxanes and capecitabine have been published recently.
Most recently, he participated in the launch of multiple BMS oncology drugs, including cetuximab (Erbitux([R])), dasatinib (Sprycel([R])) and ixabepilone (Ixempra([R])).
 
 
 
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