itai-itai disease


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i·tai-·i·tai dis·ease

a form of cadmium poisoning described in some Japanese people, characterized by renal tubular dysfunction, osteomalacia, pseudofractures, and anemia, caused by ingestion of contaminated shellfish or other sources containing cadmium.
A form of renal osteodystrophy—osteomalacia with marked bone pain and painful fractures—described in multiparous Japanese women due to cadmium accumulation in bone, caused by industrial pollutants
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They also pose a number of health hazards to humans such as Cd intake can lead to itai-itai disease, mercury accumulation may cause minimata disease and As intake through contaminated drinking water can cause poisoning [5].
Itai-Itai disease, which affected thousands of people in Japan and even many lead to death, was caused by Cd (Baby et al.
Combined effects of estrogen deficiency and cadmium exposure on calcified hard tissues: Animal model relating to itai-itai disease in postmenopausal women Mitsuo Kakei, Toshiro Sakae and Masayoshi Yoshikawa Communicated by Tatsuo Suda, M.
4-6) The development of itai-itai disease has generally been attributed to the renal tubular dysfunction induced by Cd exposure.
An estimate of cadmium intake, based on historic rice cadmium content, in the Itai-itai disease endemic area during the 1960s was 600 [micro]g/day, and the threshold lifetime intake was estimated to be between 1,580 and 2,000 mg of cadmium (67,68).
It has been documented that Itai-itai disease was caused by large amounts of cadmium in the village's water supply of Toyama city, Japan, from 1939 to 1954.
The typical patient with itai-itai disease was reported to be a middle aged postmenopausal multiparous woman who had lumbar pains, leg myalgia, and ducklike gait.
Cadmium, a toxic metallic element, is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
Cadmium is known to be the cause of Itai-itai Disease, considered to be a type of acquired Fanconi Syndrome characterized by kidney dysfunction and osteomalacia, which plagued a number of people, mainly women, in Toyama Prefecture in the 1950s.
Residents of low-lying areas along the river in Toyama Prefecture were the main people affected by the condition, which caused severe twinges and became known as the Itai-Itai Disease.
Although first reported in French workers by Nicaud et al (7), toxic effects of Cd on the bones really became evident with the outbreak of the Itai-Itai disease in the Cd-polluted area of Toyama, Japan, after World War II.
The toxic effect of cadmium on bone became evident at the outbreak of Itai-itai disease in Japan, where severe renal and skeletal damage in women was associated with consumption of heavily cadmium-polluted rice (Kjellstrom 1992).