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isotype
(redirected from isotypic)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.03 sec.
i·so·type (s-tp)
n.
An antigenic marker that occurs in all members of a subclass of an immunoglobulin class.

iso·typic (-tpk) adj.

isotype
[ī′sətīp]
an antigenic determinant that occurs in all members of a subclass of an immunoglobulin class. An antigenic determinant that is isotypic in one subclass may appear as an allotypic marker in another class.

isotype
the antigenic variability between related proteins, e.g. between immunoglobulin classes of a single species.


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The percentage of events reactive with each monoclonal antibody was determined, setting thresholds with isotypic controls.
3] at 4[degrees]C for 15 min with optimal concentrations of antibodies: a) memory helper T cells: CD4-FITC/CD45RO-PE; b) memory cytotoxic T cells: CD8-FITC/CD45RO-PE; c) activated cytotoxic T cells: CD8-FITC/HLADR-PE; d) activated T cells bearing the IL-2 receptor: CD3-FITC/CD25-PE; and e) isotypic controls IgG-FITC and IgG-PE.
In an additional experiment, the primary antibody was replaced with isotypic mouse immunoglobulin IgG2b (Sigma) at the same concentration.
 
 
 
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