isosorbide


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isosorbide

 [i″so-sor´bīd]
an osmotic diuretic used to reduce intraocular pressure; its dinitrate and mononitrate esters are as coronary vasodilators in treatment of coronary insufficiency and angina pectoris.

i·so·sor·bide

(ī'sō-sōr'bīd),
A compound with diuretic properties prepared by acid dehydration of d-glucitol.

isosorbide

/iso·sor·bide/ (i″so-sor´bīd) an osmotic diuretic used to reduce intraocular pressure; its dinitrate and mononitrate esters are used as coronary vasodilators to treat coronary insufficiency and angina pectoris.

glycerol trinitrate

; GTN; isosorbide potent coronary vasodilator drugs, presented as sublingual spray or tablet, used in the treatment of angina; may cause flushing, headache and postural hypotension; patients develop tolerance over time with resultant reduced therapeutic effect

isosorbide

an osmotic diuretic; the dinitrate of isosorbide is used as a coronary vasodilator.
References in periodicals archive ?
Global Isosorbide market is forecast to grow at a CAGR of 19.
Resins and polymers emerged as the largest end-use industry for isosorbide and accounted for over 60% of the global demand in 2012.
First, pure poly(L-lactide) for all polymerization methods was synthesized, and this process is followed by the synthesis of three polymers, with isosorbide in the middle of polymer chains with desired molecular weights of 20,000, 40,000, and 60,000 g [mol.
Supplementary analysis has been carried out on sorbitol potential as a platform chemical for the production of polyols (ethylene glycols, propylene glycols and glycerols) and isosorbides.
Treatment with PE low dose and PE high dose, just as with isosorbide dinitrate, both inhibited the AMI-induced increases in serum TNF-[alpha] (Fig.
Isosorbide dinitrate therapy may aggravate angina associated with hypertrophic cardiomyopathy.
involved 1,050 African American heart failure patients randomized in a double-blind fashion to BiDil titrated to a target dose of 120 mg/day of isosorbide dinitrate plus 225 mg/day of hydralazine or to placebo, along with state-of-the-art medical management.
The study was halted secondary to a higher mortality rate in the placebo group than in the group given isosorbide dinitrate plus hydralazine.
Less than a month later, NitroMed went public, raising $66 million (even though isosorbide dinitrate and hydralazine are available separately in generic formulations, making it possible to closely approximate NitroMed's combination at a cost of about 44 cents per dose).
5 mg hydralazine hydrochloride and 20 mg isosorbide dinitrate, which have been approved separately for treating hypertension (hydralazine) and angina (isosorbide dinitrate) for more than 40 years.
The new drug, Imazin XL, works by combining aspirin with isosorbide mononitrate, another standard angina treatment.