market is forecast to grow at a CAGR of 19.
Resins and polymers emerged as the largest end-use industry for isosorbide
and accounted for over 60% of the global demand in 2012.
First, pure poly(L-lactide) for all polymerization methods was synthesized, and this process is followed by the synthesis of three polymers, with isosorbide
in the middle of polymer chains with desired molecular weights of 20,000, 40,000, and 60,000 g [mol.
Supplementary analysis has been carried out on sorbitol potential as a platform chemical for the production of polyols (ethylene glycols, propylene glycols and glycerols) and isosorbides
Treatment with PE low dose and PE high dose, just as with isosorbide
dinitrate, both inhibited the AMI-induced increases in serum TNF-[alpha] (Fig.
, a versatile dianhydrosugar compound derived from sorbitol is hydrophilic and thermally stable.
dinitrate therapy may aggravate angina associated with hypertrophic cardiomyopathy.
involved 1,050 African American heart failure patients randomized in a double-blind fashion to BiDil titrated to a target dose of 120 mg/day of isosorbide
dinitrate plus 225 mg/day of hydralazine or to placebo, along with state-of-the-art medical management.
The study was halted secondary to a higher mortality rate in the placebo group than in the group given isosorbide
dinitrate plus hydralazine.
Less than a month later, NitroMed went public, raising $66 million (even though isosorbide
dinitrate and hydralazine are available separately in generic formulations, making it possible to closely approximate NitroMed's combination at a cost of about 44 cents per dose).
5 mg hydralazine hydrochloride and 20 mg isosorbide
dinitrate, which have been approved separately for treating hypertension (hydralazine) and angina (isosorbide
dinitrate) for more than 40 years.
The new drug, Imazin XL, works by combining aspirin with isosorbide
mononitrate, another standard angina treatment.