isoproterenol


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isoproterenol

 [i″so-pro-ter´ĕ-nol]
a synthetic adrenergic, used in the form of the hydrochloride and sulfate salts as a bronchodilator, and in the form of the hydrochloride salt as a cardiac stimulant.

i·so·pro·te·re·nol

(ī'sō-prō-ter'ĕ-nol),
A sympathomimetic β-receptor stimulant possessing the cardiac excitatory, but not the vasoconstrictor, actions of epinephrine. Chemically it differs from epinephrine in having an isopropyl group replacing the methyl group attached to the nitrogen atom; rarely used because of the availability of more specific agents.

isoproterenol

/iso·pro·te·re·nol/ (-pro-ter´ĕ-nol) a sympathomimetic used in the form of the hydrochloride and sulfate salts as a bronchodilator, and in the form of the hydrochloride salt as a cardiac stimulant.

i·so·pro·te·re·nol

(ī'sō-prō-ter'ĕ-nol)
Sympathomimetic β-receptor stimulant possessing cardiac excitatory, but not the vasoconstrictor, actions of epinephrine.

isoproterenol

a synthetic cathecholamine and potent β-receptor agonist; it causes vasodilation and positive inotropic and chronotropic effects in the heart. Called also isoprenaline.
References in periodicals archive ?
Effects of lipic acid on plasma metabolites and metabolic response to intravenous injection of isoproterenol in broilers.
Key words: Caffeic acid phenethyl ester, isoproterenol, myeloperoxidase, myocardial infarction, lipid peroxidation, oxidative stress
CGP12,177 stimulates basal lipolysis in rat adipocytes, as well as inhibiting response to isoproterenol.
In addition, the [beta]-adrenergic agonist isoproterenol produced marked stimulatory effect in the presence of [10.
Animals treated with isoproterenol develop decreased heart rate, poor contractility ("squeeze"), and increased pressure inside the heart, which leads to heart failure.
In their experiments, the researchers "fed" the normal and diabetic hearts excess glucose and stimulated the hearts to beat faster by bathing them in a hormone-like substance, isoproterenol, which acts like the body's natural catecholamine, activated when a person is under stress or participating in high levels of physical activity.
Drugs: Acetoximetilester of Fura-2 (Fura-2/AM), type 1A collagenase, isoproterenol hydrochloride, verapamil hydrochloride, N-2-hydroxyethylpiperazine-N'-2-etanosulfonic acid (HEPES) and trypsin were purchased from Sigma-Aldrich (USA).
The compounds or a control substance were combined and administered with the beta-agonist bronchodilator drug isoproterenol.
Protective role of curcumin against isoproterenol induced myocardial infarction in rats.
Importantly, increases in plasma miR-208 after isoproterenol administration were correlated with increases in circulating concentrations of cardiac troponin.
Similar results have been seen with lead, which has also increased BP in rats and caused higher HR responses to dobutamine and isoproterenol than seen in unexposed rats (Reza et al.
In contrast, isoproterenol that mimics cardiac stimulation by the sympathetic system causes arrhythmias in single cells only in LQT1 heart cells.