Rhophylac is indicated for suppression of rhesus (Rh) isoimmunization
in: -- Pregnancy and obstetric conditions in non-sensitized, Rh(0)(D)-negative women with an Rh-incompatible pregnancy, including routine antepartum and postpartum Rh prophylaxis and Rh prophylaxis in cases of obstetric complications, invasive procedures during pregnancy, or obstetric manipulative procedures.
double dagger]) Pre-existing conditions: malpresentation, genital herpes simplex virus, diabetes mellitus or abnormal glucose tolerance, hypertensive disorder, oligohydramnios, congenital or acquired abnormality of vagina, other congenital or acquired abnormality, phesus (anti-D) isoimmunization
Herein we describe a preterm neonate with hydrops fetalis due to Kell isoimmunization
that was detected during the postnatal period, and discuss the perinatal approach to this rare condition.
The study included 111 fetuses at risk for hemolytic disease of the newborn due to red cell isoimmunization
, and 265 healthy fetuses.
Additionally, during this time, infants may have incurred additional Hg exposure through breast milk if they were born to mothers with Hg amalgam fillings and/or Rh-negative mothers, since many Rho(D)-immune globulin formulations, used to prevent isoimmunization
in the Rho(D) negative individual exposed to Rho(D) positive foetal blood, contained thimerosal (10.
Bill Liley (later Sir William of Rhesus isoimmunization
fame) was there.
Modern methods for diagnosing and treating Rh isoimmunization
have also made a dramatic difference in fetal death rates.
2]--Hypoxemia Lung disease Respiratory distress syndrome Sepsis Persistent pulmonary hypertension Diaphragmatic hernia Congenital heart disease with right-to-left shunt Transposition of the great vessel Pulmonary atresia Low hemoglobin--anemia Fetal-to-maternal transfusion, chronic twin to twin transfusion Hemolysis Isoimmunization
Blood drawing Table 3.
NABI also has two immunotherapeutic products already on the market: H-BIG(R), for the prevention of Hepatitis B, and WinRho SD(R), for the treatment of Immune Thrombocytopenic Purpura (ITP), an immune platelet disorder, and for the suppression of Rh isoimmunization
Despite the widespread use of prophylactic Rh immunoglobulin, Rh isoimmunization
during pregnancy still occurs and is a significant cause of neonatal morbidity and mortality (2).
NABI also has two immunotherapeutic products already on the market: H-BIG, for the prevention of hepatitis B, and WinRho SD(R), for the treatment of idiopathic thrombocytopenic purpura [ITP, an immune platelet disorder], and for the suppression of Rh isoimmunization
of Winnipeg, Canada to manufacture WinRho SD(TM) (Rho (D) Immune Globulin Intravenous (Human)) for the suppression of Rh isoimmunization
, and the treatment of children with chronic and acute immune thrombocytopenic purpura (ITP), adults with chronic ITP, and children and adults with ITP secondary to HIV infection.