Glabridin, an isoflavan
from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock.
Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway.
Glabridin, An isoflavan from licorice root, down-regulates iNOS expression and activity under high glucose stress and inflammation.
In vitro and in vivo, two natural compounds derived from licorice root demonstrated estrogen like activity on vascular tissues: glabrene, an isoflavene, behaved as a partial agonist/antagonist of estradiol while glabridin, the major isoflavan
, demonstrated only estrogenic activity (Somjen 2004b).
Structural elucidation of hidroxylated metabolites of isoflavan
equol by GC/MS and HPLC/MS.
Licorice root extract, as well as its major isoflavan glabridin, is a potent antioxidant against LDL oxidation in mice and humans (Rosenblat et al.
The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.
The same effect was reported for glabridin, an isoflavan
from licorice (Belinky et al.