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isochromosome

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isochromosome /iso·chro·mo·some/ (-kro´mah-sōm) an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.
i·so·chro·mo·some (s-krm-sm)
n.
A chromosomal aberration in which two daughter chromosomes are formed, each lacking one chromosome arm but with the other arm doubled.

isochromosome
[-krō′məsōm]
a chromosome whose arms are of equal length.

isochromosome [i″so-kro´mo-sōm]
an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.

isochromosome
an abnormal chromosome having a median centromere and two identical arms, formed by transverse, rather than normal longitudinal, splitting of a replicating chromosome.


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A high incidence of isochromosome 12p in leukaemic blasts has been reported and this is a genetic abnormality found in EGCT and gonadal GCT [23].
Thirty-eight (67%) of the cases with chromosomal abnormalities were karyotype 45,X; the rest of the observed chromosomal abnormalities were 45,X/47,XXX (n = 1), trisomy 21 (n = 7), trisomy 18 (n = 5), trisomy 13 (n = 2), triploidy (n = 1), tetraploidy (n = 1), isochromosome 22 (n = 1), and addition chromosome 4 (n = 1).
 
 
 
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