islet cell antibodies

islet autoantibodies

, islet cell antibodies,

ICA

Antibodies formed against insulin, glutamic acid decarboxylase, or protein tyrosine phosphatase-like molecules. They are serum markers for type 1 diabetes mellitus (DM). Children whose parents have type 1 DM and who have these markers present in their serum have a high risk of developing type 1 DM.

islet cell antibodies

Autoantibodies to the cytoplasm of the insulin-producing beta cells of the islets of Langerhans in the pancreas. Autoimmune damage to the beta cells is the main cause of DIABETES, and the presence of these antibodies and of antibodies to glutamic acid decarboxylase (which are markers of autoimmune beta cell damage) can be a predictor of diabetes.
References in periodicals archive ?
Markers being characteristic for Type 1 diabetes and LADA are islet cell antibodies (1CA), glutamatedecarboxylase antibodies (GAD-A) and tyrosinphosphatase antibodies ([IA.
The World Health Organization International Collaborative Study for islet cell antibodies.
Surrey Pathology Services~ Department of Immunology requires an automated Immunofluorescence slide processor to run ANCA, Hep-2, tissue screen and endomysial antibody slides with associated reagents and consumables and additional slides for manual tests such as adrenal and islet cell antibodies.
The presence of autoantibodies, such as islet cell antibodies (ICA), anti-glutamic acid decarboxylase (anti-GAD) antibodies, and protein tyrosine phosphatase antibodies have been investigated in patients with ketosis prone type 2 diabetes, and autoantibody positivity has been reported in 0% to 18% of patients (4,10,19).
Detection of islet cell antibodies is not recommended for routine diagnosis of diabetes or for screening.
Islet cell antibodies and glutamic acid decarboxylase antibodies but not the clinical phenotype help to identify type 1V2 diabetes in patients presenting with type 2 diabetes.
Proinsulin autoantibodies: association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type.
The emerging clinical use is the screening of a subset of patients with type 2 diabetes for autoantibodies, particularly GAD65 and islet cell antibodies, to identify those with possible slow-onset type 1 diabetes.
Report of the First International Workshop on the Standardisation of Cytoplasmic Islet Cell Antibodies.
Islet cell antibodies (ICA, antibodies reacting against the islets of Langerhans) constitute a well-known autoimmune marker of IDDM, which may be detected in 85% of children at the time of diagnosis of the disease [1].
INDEXING TERMS: diabetes * autoimmunity * islet cell antibodies * method comparison * ROC curve analysis