islet autoantibodies


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Related to islet autoantibodies: GAD antibodies

islet autoantibodies

, islet cell antibodies,

ICA

Antibodies formed against insulin, glutamic acid decarboxylase, or protein tyrosine phosphatase-like molecules. They are serum markers for type 1 diabetes mellitus (DM). Children whose parents have type 1 DM and who have these markers present in their serum have a high risk of developing type 1 DM.
References in periodicals archive ?
However, these are broad and prospective studies in which a large number of relatives were included for different islet autoantibodies screening and followed up to predict DM development as the presence of these antibodies is highly predictive for future DM; 3-5 years risk may reach 28-66%.
Others found that the development of persistent islet antibodies is associated with human leukocyte antigen (HLA) DR3-DQ2 / DR4-DQ8 genotype, both in relatives of T1DM and in children from general population, whereas transient islet autoantibodies were not correlated with known genetic factors.
Quantification of islet autoantibodies has proved difficult.
It is generally accepted at the time of initial detection of fasting hyperglycemia that between 85% and 90% of individuals with type 1 diabetes will have islet autoantibodies (3).
Although the development of diabetes was not addressed directly in either study, both teams of investigators suggest that refraining from introducing cereals at these high-risk times could reduce an at-risk child's likelihood of developing the autoimmune disease by minimizing the presence of pancreatic islet autoantibodies Studies have linked high levels of these antibodies in children to juvenile diabetes.
sup][61] ZnT8A was found in nearly 30% other islet autoantibodies negative patients.
The frequency of islet autoantibodies in black patients with type 1 diabetes is reportedly lower than in whites, and this might therefore have affected both sensitivity and specificity analyses.
Islet autoantibodies have historically been relied upon as indicators of the presence of islet autoimmunity in diabetes patients.
Islet autoantibodies are considered unlikely to be the cause of T1DM.
0602 haplotype confers dominant protection from T1D, even in the presence of islet autoantibodies (21).
Individuals classified with type 2 diabetes but positive for islet autoantibodies (representing slow-onset type 1 diabetes, latent autoimmune diabetes in the adult, or type 1.