9) Unlike the irreversible inhibition
of CYP3A4 by furanocoumarins, flavanoids effects on OATPs have been shown to decrease within 4 hours.
An assay procedure for TAase was developed based on the irreversible inhibition
of Glutathione-S-transferase (GST) by PA, the extent of inhibition of GST was considered proportional to the activity of TAase.
KEY WORDS: aromatic amine carcinogens, arylamine N-acetyltransferases, cadmium, irreversible inhibition
, xenobiotic metabolism.
a biotechnology company developing novel targeted covalent drugs, has demonstrated the first-ever selective irreversible inhibition
of a viral protease using a targeted covalent drug.
Catalytic irreversible inhibition
of Trypanossomo brucei ornithine decarboxylase (E.
It was therefore thought that if the [alpha],[beta]-unsaturated ester moiety is incorporated into the basic structural frame of a simple substrate in such a way that it would bind the enzyme with its carbonyl group being coordinated to the zinc ion, then a Michael type addition reaction may occur on the [alpha],[beta]-unsaturated acid or ester by the catalysed carboxylate in ACE, leading to irreversible inhibition
of the enzyme.
Several large trials demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel, a thienopyridine that causes irreversible inhibition
of the platelet ADP receptor [P2Y.
Since aspirin causes irreversible inhibition
of platelet function and other clotting disorders, its use near term may enhance maternal blood loss at delivery and increase the incidence of intracranial hemorrhage in premature infants.