irreversible inhibition


Also found in: Encyclopedia.

irreversible inhibition

the action of an inhibitor such that, once bound to a protein, it cannot dissociate.
References in periodicals archive ?
9) Unlike the irreversible inhibition of CYP3A4 by furanocoumarins, flavanoids effects on OATPs have been shown to decrease within 4 hours.
An assay procedure for TAase was developed based on the irreversible inhibition of Glutathione-S-transferase (GST) by PA, the extent of inhibition of GST was considered proportional to the activity of TAase.
KEY WORDS: aromatic amine carcinogens, arylamine N-acetyltransferases, cadmium, irreversible inhibition, xenobiotic metabolism.
a biotechnology company developing novel targeted covalent drugs, has demonstrated the first-ever selective irreversible inhibition of a viral protease using a targeted covalent drug.
It was therefore thought that if the [alpha],[beta]-unsaturated ester moiety is incorporated into the basic structural frame of a simple substrate in such a way that it would bind the enzyme with its carbonyl group being coordinated to the zinc ion, then a Michael type addition reaction may occur on the [alpha],[beta]-unsaturated acid or ester by the catalysed carboxylate in ACE, leading to irreversible inhibition of the enzyme.
Several large trials demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel, a thienopyridine that causes irreversible inhibition of the platelet ADP receptor [P2Y.
Since aspirin causes irreversible inhibition of platelet function and other clotting disorders, its use near term may enhance maternal blood loss at delivery and increase the incidence of intracranial hemorrhage in premature infants.