Development of a liquid chromatography tandem mass spectrometry method for iothalamate
measurement to assess renal function for potential kidney donation.
Within the large population of patients with previously diagnosed chronic kidney disease (CKD) that were studied, sex, race, and age were the most important variables that influenced serum creatinine correlations with GFR measured by iothalamate
They demonstrated that heme oxygenase-1 induction by cobalt protoporphyrin could prevent the increase in plasma creatinine and in superoxide ion formation in both the cortex and medulla in uninephrectomized, salt depleted male Sabra rats treated with the RCM sodium iothalamate
compared with untreated rats.
Among other tests is the iothalamate
Sequential radiographs were taken as iothalamate
meglumine radiographic contrast material (Conray 60) was injected through the catheter.
Clinical DN was diagnosed by the presence of albumin excretion and creatinine clearance based on standardized 4 hours collection and by periodic iothalamate
injection of the HOCM, iothalamate
, with the IOCM, iotrolan, and found that outer medullary hypoperfusion was pronounced by iotrolan versus iothalamate
Imprecision of urinary iothalamate
clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations.
Using exogenous filtration markers, such as inulin, iothalamate
, EDTA, and iohexol, to measure GFR is complex, cumbersome, and costly, and usually not available outside of research settings.
Type Ionicity Generic name Iodine content (mg/mL) HOCM Ionic monomer Diatrizoate 300-370 HOCM Ionic monomer Metrizoate 280-370 HOCM Ionic monomer Iothalamate
141-480 LOCM Ionic dimer Ioxaglate 280-320 LOCM Nonionic monomer Iohexol 140-350 LOCM Nonionic monomer Iopamidol 150-370 LOCM Nonionic monomer Iopromide 150-400 LOCM Nonionic monomer Iopentol 150-350 LOCM Nonionic monomer Iomeprol 150-400 IOCM Nonionic dimer Iodixanol 270-320 IOCM Nonionic dimer Iotrolan 240-300 Type Osmolality Viscosity at Viscosity at 20-25[degrees] 37[degrees]C C (mPa x S) (mPa x S) HOCM 1500-2000 3.
The use of unlabeled iothalamate
and iohexol eliminate the issues related to radiation (36).
99m]Tc-DTPA, which can overestimate or underestimate GFR measured by urinary clearance of iothalamate