inverse agonist


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Related to inverse agonist: Partial agonist

inverse agonist

A drug that binds the same cellular receptors as an agonist, but elicits a negative, or opposing cellular response.
See also: agonist
References in periodicals archive ?
Pimavanserin possesses potent 5-HT2A inverse agonist properties required to manage psychosis in PD patients, but lacks clozapine's affinities for [alpha]-1 adrenergic, muscarinic, or histaminergic receptors that contribute to clozapine's poor tolerability.
3) Inverse agonists bind to the same receptor as a normal neurotransmitter or agonist but induce the opposite effect (rather than just preventing neurotransmitter or agonist actions by blocking their interaction with the receptor).
The patent relates to a class of inverse agonists to the 5-HT2A serotonin receptor, which is thought to be involved in the regulation of sleep architecture and sleep maintenance.
The invention also concerns the inverse agonist effect of ML 10375 on 5-HT4(c) and 5-HT4(d) receptors.