inulin clearance


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Related to inulin clearance: creatinine clearance

in·u·lin clear·ance

an accurate measure of the rate of filtration through the renal glomeruli, because inulin filters freely with water and is neither excreted nor reabsorbed through tubule walls. Inulin is not a normal constituent of plasma and must be infused continously to maintain a steady plasma concentration and a steady rate of urinary excretion during the measurement. Inulin clearance in a normal adult person is about 120 mL/min (range, 100-150) per 1.73 m2 body surface area.

inulin clearance

a test of the rate of filtration of a starch, inulin, in the glomerulus of the kidney. Inulin is given by mouth, and the glomerular filtration rate can be estimated from the amount of inulin that appears in the urine. The clearance rate of inulin in urine for adults with normal renal function is 100 to 150 mL/min.

in·u·lin clear·ance

(in'yū-lin klēr'ăns)
An accurate measure of the rate of filtration through the renal glomeruli, because inulin filters freely with water and is neither excreted nor reabsorbed through tubule walls. Inulin is not a normal constituent of plasma and must be infused continously to maintain a steady plasma concentration and a steady rate of urinary excretion during the measurement.

clearance

the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.

blood-urea clearance
the volume of the blood cleared of urea per minute by renal elimination.
Bromsulphalein clearance
see sulfobromophthalein clearance test.
creatinine clearance
inulin clearance
see inulin clearance.
clearance time
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.
urea clearance
blood-urea clearance.

inulin

a starch occurring in the rhizome of certain plants, which on hydrolysis yields fructose. It is used to measure glomerular function in tests of renal function.

inulin clearance
an expression of the renal efficiency in eliminating inulin from the blood, a measure of glomerular function.
References in periodicals archive ?
We investigated whether inulin clearance could be estimated accurately with a smaller number of blood samples.
The covariates BSA and HUS correlated significantly with inulin clearance and were included in the final model.
For all of the tested sampling strategies, we found that inulin clearance was assessed well by Bayesian estimation when at least a sample at 240 min was included.
Sampling strategies 1 (10/30/90/240 min), 4 (10/30/ 240 min), 5 (10/90/240 min), 6 (30/90/240 min), and 9 (90/240 min) allowed accurate prediction of inulin clearance with a bias not significantly different from 0 and an imprecision not exceeding 15%.
In conclusion, sampling strategies of two to four sampling times and a total sampling time of 240 min allow good prediction of inulin clearance in children with a nonsignificant bias and good imprecision (<15%).
2] by inulin clearance as a result of various renal disorders.
63) compared serum concentrations of CysC and SCr to GFR determined by inulin clearance in 44 patients with liver cirrhosis with no evidence of renal disease.
Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population.
Plasma cystatin C values and inulin clearances in premature neonates [Letter].
Elke Weber and Christine Wrobel have been very helpful in preparing and performing the inulin clearance examinations at our center for many years.