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intron |
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intron /in·tron/ (in´tron) a noncoding sequence between two coding sequences within a gene, processed out in the formation of mature mRNA.
intron [in′tron] Etymology: L, intra, within, regin, region a sequence of nucleotides in eukaryotic DNA that does not code for amino acids and interrupts the coding sequence of a gene. Some genes contain numerous long introns. Compare exon. intron untranslated, intervening sequences that are interspersed between coding sequences of a particular gene of almost all eukaryocytic genes and which are excised from the primary RNA transcript to yield mRNA. intron-exon junction introns are removed by the catalytic action of small nuclear riboproteins (snRNPs) which bind to special recognition sequences at the 5,(donor junction) and 3,(receptor junction) to form a complex called a spliceosome. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian cases. Recent work has demonstrated that intronic mutations can have functional consequences in some genes such as p53 (Lehman et al. 5 kb downstream of the last exon, and a significant amount of intronic sequence have been examined. |
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