intrinsic pathway


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Related to intrinsic pathway: Extrinsic pathway

intrinsic pathway

Hematology An arm of the coagulation cascade, initiated by negatively charged surfaces–contact factors–eg, sulfatide micelles, kaolin which bind factor XII and HMW kininogen–HMWK; HMWK binds prekallikrein and factor XI, activating the latter; XIa then activates IX which in turn activates factor X, initiating the common pathway. See Common pathway, Extrinsic pathway.

Intrinsic pathway

One of three pathways in the coagulation cascade.
References in periodicals archive ?
2008), while the intrinsic pathway begins with intracellular stress-mediated dysfunction of the mitochondria (Tait and Green 2010).
lucidum inhibited the intrinsic pathway in blood coagulation and exhibited concentration dependent anticoagulation effects [21].
For instance, by setting the initial values of FasL, Casp8, granB, and Casp10 to 0 and computing only those equations in blocks B and D of Table 2, we turn off the extrinsic and perforin pathways and hence obtain the apoptosis level contributed by the intrinsic pathway only.
Induction of apoptosis in CAOV-3 cells via the intrinsic pathway after cleistopholine treatment was confirmed as shown in Figs.
Interestingly, hydrolysates in solution (10 [micro]L) (Figure 3C and D) added to diluted plasma abolished TG, since maximum absorbance of active thrombin formed was decreased; therefore, higher effects on the intrinsic pathway were observed than those of intact Am-2, except at 5 h time (~14 kDa), which still presented a similar level of inhibitory action at 57 min.
The intrinsic pathway can be activated by internal trauma, which causes blood vessels to constrict and platelets to clump together, attaching to the injured site.
The involvement of a mitochondria-mediated intrinsic pathway in the pro-apoptotic action of DHB was also investigated.
Some recommended procedures for acquiring samples for coagulation analysis, especially those involving the measurement of D-dimer and fibrinogen by the Clauss method, mandate that the first sample be discarded because tissue thromboplastin released by the trauma of venipuncture could interfere with coagulation assays by activating intrinsic pathway (2).
TTP889 is the only known selective small molecule inhibitor of Factor IX/IXA, a key enzyme of the intrinsic pathway of the blood coagulation system.
Un-phosphorylated form of GSK3[beta] is involved in the activation of caspase-9 dependent intrinsic pathway and death-receptor initiated extrinsic apoptosis pathway is inhibited by this protein (Fulda and Debatin 2006).
These data in combination with those of others (2) suggest that in erythroid differentiation, an intrinsic pathway is activated with apoptotic features, although other features of apoptosis, such as differential binding of Annexin V, are lacking.