intravenous immune globulin


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Related to intravenous immune globulin: Intravenous immunoglobulin

intravenous immune globulin

A formulation of concentrated antibodies–aka immune globulins, predominantly IgG, prepared by pooling plasma from ±1000 donors, with a broad spectrum of activity against CMV, HAV, HBV, measles, rubella, tetanus, varicella zoster Indications LBW children with repeated infections, children with defects in humoral immune responses–eg, AIDS, X-linked agammaglobulinemia, CVID; IVIG may be of use in ITP, autoimmune phenomena–hemolysis, neutropenia, thrombocytopenia, Kawasaki's disease Adverse effects Pyrogenic, hypersensitivity, anaphylaxis, systemic–eg, headache, myalgia, fever, vasomotor and cardiovascular abnormalities, BP lability, tachycardia. Cf Human immune globulin.

intravenous immune globulin

Abbreviation: IVIG, IGIV
An immune globulin preparation used intravenously in patients with immunodeficiency syndromes and in immunosuppressed recipients of bone marrow transplants. Together with aspirin, it is the standard of care for children during the first 10 days of Kawasaki disease to prevent the development of coronary aneurysms.

IVIG is also used to treat idiopathic thrombocytopenic purpura and Guillain-Barré syndrome as well as to prevent bacterial infections in patients with hypogammaglobulinemia or recurrent infections associated with B-cell chronic lymphocytic leukemia.

CAUTION!

The administration of sucrose-containing IVIGs has been associated with acute renal failure, which in about 10% of patients has proved fatal. Patients should be hydrated before being treated with IVIG.
See also: globulin
References in periodicals archive ?
The paper concluded that "the combination of rituximab and intravenous immune globulin is effective in patients with refractory pemphigus vulgaris.
The new facility, based in Los Angeles, California is anticipated to be operational in 2013 and will expand the Company's ability to supply its new generation of intravenous immune globulin into the foreseeable future.
BIVIGAM is a sugar-free, glycine stabilized intravenous immune globulin that was approved by the FDA on December 19, 2012 and is available in 50 mL (5 gram) and 100 mL (10 gram) tamper-evident vials.
The Company's technology fundamentally changes the economics of blood plasma fractionation by substantially increasing the yield of alpha-1 antitrypsin (AAT) and intravenous immune globulin (IVIG) and makes possible the extraction of several additional therapeutically useful plasma proteins.
LOS ANGELES, November 22, 2010 /PRNewswire/ -- Grifols today announced availability of its recently approved Flebogamma(R) 10% DIF intravenous immune globulin.
Until now, there has been no FDA-approved dosing regimen for an effective course of intravenous immune globulin therapy to reduce neuromuscular disability and improve quality of life in patients with CIDP.
ATLANTA -- Intravenous immune globulin should be the primary means of post-exposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
The new clinical investigation involves a combined treatment of therapeutic plasmapheresis and the administration of human albumin and intravenous immune globulin (IVIG) at different doses and frequencies.
ATLANTA -- Intravenous immune globulin should be the primary means of postexposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
Intravenous immune globulin also has been used in treatment, and anecdotal reports suggest that there have been good outcomes, Dr.
AOM has been a full-line home infusion provider since 1994 and has developed recognized expertise in this field including the outpatient treatments using Total Parenteral Nutrition (TPN), as well as Intravenous Immune Globulin (IVIG), Antibiotics, Inotropic Therapy and many other therapies.
FDA will revisit its intravenous immune globulin Phase III clinical trial design recommendations in light of decreased adverse event rates for the therapies, The Pink Sheet reports, "We need to go back and look at our data sets and the basis for some of our calculations and recalculate them and come up with a more updated trial design," Center for Biologics Evaluation & Research Division of Hematology Director Basil Golding said recently at an FDA IGIV workshop at the National Institutes of Health.

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