intravenous immune globulin

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Related to intravenous immune globulin: Intravenous immunoglobulin

intravenous immune globulin

A formulation of concentrated antibodies–aka immune globulins, predominantly IgG, prepared by pooling plasma from ±1000 donors, with a broad spectrum of activity against CMV, HAV, HBV, measles, rubella, tetanus, varicella zoster Indications LBW children with repeated infections, children with defects in humoral immune responses–eg, AIDS, X-linked agammaglobulinemia, CVID; IVIG may be of use in ITP, autoimmune phenomena–hemolysis, neutropenia, thrombocytopenia, Kawasaki's disease Adverse effects Pyrogenic, hypersensitivity, anaphylaxis, systemic–eg, headache, myalgia, fever, vasomotor and cardiovascular abnormalities, BP lability, tachycardia. Cf Human immune globulin.

intravenous immune globulin

Abbreviation: IVIG, IGIV
An immune globulin preparation used intravenously in patients with immunodeficiency syndromes and in immunosuppressed recipients of bone marrow transplants. Together with aspirin, it is the standard of care for children during the first 10 days of Kawasaki disease to prevent the development of coronary aneurysms.

IVIG is also used to treat idiopathic thrombocytopenic purpura and Guillain-Barré syndrome as well as to prevent bacterial infections in patients with hypogammaglobulinemia or recurrent infections associated with B-cell chronic lymphocytic leukemia.


The administration of sucrose-containing IVIGs has been associated with acute renal failure, which in about 10% of patients has proved fatal. Patients should be hydrated before being treated with IVIG.
See also: globulin
References in periodicals archive ?
Intravenous immune globulin (IVIG) appears to be as effective as plasmaphoresis for the treatment of GBS as per the American Academy of Neurology (AAN) practice guidelines3.
4) Heidari, wearing the pump that delivers life-saving IntraVenous Immune Globulin, tends to her work as a fashion designer in her home studio.
As with other intravenous immune globulin products, the infusion should be started slowly.
Under the contract, Biotest Pharmaceuticals will offer manufacturing services and license proprietary fractionation and purification manufacturing process for Respiratory Syncytial Virus intravenous immune globulin to ADMA Biologics.
Warnings about the risk of thrombotic events in patients who receive human intravenous immune globulin have been issued by the American Red Cross and Baxter Healthcare Corp.
Intravenous immune globulin also has been used in treatment, and anecdotal reports suggest that there have been good outcomes, Dr.
Several years ago, a small open study of intravenous immune globulin found significant improvements in eye contact, speech and verbal behavior.
ADMA's lead product candidate is a plasma-derived, polyclonal, Intravenous Immune Globulin or IGIV, prepared with high levels of antibodies against Respiratory Syncytial Virus, or RSV.
RI-001 is a plasma-derived, polyclonal, Intravenous Immune Globulin or IGIV, with standardized high levels of antibodies against Respiratory Syncytial Virus, or RSV.
Proceeds from the financing will support ADMA's pivotal Phase III clinical trial for its lead product candidate, RI-001, in order to gain FDA approval of RI-001 as an intravenous immune globulin ("IGIV") for the treatment of patients with Primary Immunodeficiency Disease ("PIDD").
of The Rockefeller University and Virdante's scientific founder, previously discovered that DC-SIGN binds a sialylated Fc fragment of IgG antibodies that is required for the anti-inflammatory activity of plasma-derived intravenous immune globulin ("IVIG").

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