intravenous immune globulin
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Related to intravenous immune globulin: Intravenous immunoglobulin
intravenous immune globulinA formulation of concentrated antibodies–aka immune globulins, predominantly IgG, prepared by pooling plasma from ±1000 donors, with a broad spectrum of activity against CMV, HAV, HBV, measles, rubella, tetanus, varicella zoster Indications LBW children with repeated infections, children with defects in humoral immune responses–eg, AIDS, X-linked agammaglobulinemia, CVID; IVIG may be of use in ITP, autoimmune phenomena–hemolysis, neutropenia, thrombocytopenia, Kawasaki's disease Adverse effects Pyrogenic, hypersensitivity, anaphylaxis, systemic–eg, headache, myalgia, fever, vasomotor and cardiovascular abnormalities, BP lability, tachycardia. Cf Human immune globulin.
intravenous immune globulinAbbreviation: IVIG, IGIV
An immune globulin preparation used intravenously in patients with immunodeficiency syndromes and in immunosuppressed recipients of bone marrow transplants. Together with aspirin, it is the standard of care for children during the first 10 days of Kawasaki disease to prevent the development of coronary aneurysms.
IVIG is also used to treat idiopathic thrombocytopenic purpura and Guillain-Barré syndrome as well as to prevent bacterial infections in patients with hypogammaglobulinemia or recurrent infections associated with B-cell chronic lymphocytic leukemia.
CAUTION!The administration of sucrose-containing IVIGs has been associated with acute renal failure, which in about 10% of patients has proved fatal. Patients should be hydrated before being treated with IVIG.
See also: globulin