intravenous bolus

in·tra·ve·nous bo·lus

a relatively large volume of fluid or dose of a drug or test substance given intravenously and rapidly to hasten or magnify a response; in radiology, rapid injection of a large dose of contrast medium to increase opacification of blood vessels.

intravenous bolus

a relatively large dose of medication administered into a vein in a short period, usually within 1 to 30 minutes. The IV bolus is commonly used when rapid administration of a medication is needed, such as in an emergency; when drugs that cannot be diluted, such as many cancer chemotherapeutic drugs, are administered; and when the therapeutic purpose is to achieve a peak drug level in the bloodstream of the patient. The IV bolus is not used when the medication must be diluted in a large-volume parenteral fluid before entering the bloodstream or when the rapid administration of a medication, such as potassium chloride, may be life-threatening. The IV bolus is normally not used for patients who have decreased cardiac output, decreased urinary output, pulmonary congestion, or systemic edema. Such patients have decreased tolerance to medications, which therefore must be diluted more than usual and administered at slower rates. A wristwatch with a second hand is recommended for the timing of all IV bolus injections. The amount of medication to be delivered per minute is determined by dividing the total amount to be injected by the prescribed time for delivery. The IV bolus site is prepared with an appropriate antiseptic, and sterile technique is used to enter the site with a venipuncture needle. A winged-tip needle is used for administering an IV bolus because it is small enough to lessen the risk of collapsing the vein and causing trauma and is more stable than a syringe needle. If a primary IV line is already established, the IV bolus is administered by mixing the prescribed drug with the appropriate amount of diluent and then administering the drug into the primary line, after first determining whether it is compatible with the primary IV solution. Also called intravenous push.
enlarge picture
Administration of medication by intravenous bolus

in·tra·ve·nous bo·lus

(in'tră-vē'nŭs bō'lŭs)
1. A relatively large volume of fluid or dose of a drug or test substance given intravenously and rapidly to hasten or magnify a response.
2. radiology Rapid injection of a large dose of contrast medium to increase opacification of blood vessels.
References in periodicals archive ?
Ketorolac maintains pain relief at an opioid level, but is currently only available as an intravenous bolus injection.
In both the groups, surgical muscle relaxation was maintained with vecuronium 70 mcg/kg intravenous loading followed by 20 mcg/kg intravenous bolus every 30 minutes or as required.
The jugular vein was cannulated with polyethylene tube for intravenous bolus injection of tacrolimus and other drugs (indinavir and ritonavir).
Intravenous access was established and 10% dextrose at a dose of 2 cc/kg was given as an intravenous bolus and glucose infusion was started (6 mg/kg/min).
Objective: To estimate the effect of portal pressure lowering drug 'octreotide', by observing the Doppler waveform before and after the administration of intravenous bolus of octreotide and thus to assess indirectly its efficacy to lower the portal pressure.
In Hydralazine Group, 5 mg of hydralazine was given intravenously,and repeated every 20 min up to a maximum of five doses or labetalol (20-mg intravenous bolus dose followed by 40 mg if not effective within 20 min, followed by 80 mg every 20 min up to a maximum dose of 300mg).
Martindale Pharmas Phenylephrine product offers a simpler approach to product use, and can be given as an intravenous bolus injection or as a continuous infusion without the need for dilution.
Preventive effect of SOD-CHS-CAT bienzyme conjugate was examined in a rat model of endotoxic shock induced by intravenous bolus injection of 15 mg/kg lipopolysaccharide (LPS) isolated from Salmonella enterica serotype Typhimurium with subsequent monitoring of AP, HP, and mortality rate within a given time period.
Dyloject is an injectable therapy option that can be administered in a small volume intravenous bolus over 15 seconds, as opposed to other injectable non-opioid analgesics that are formulated in large volumes or require dilution prior to administration and typically require an infusion of 15 to 30 minutes to administer the full dose.
However, the dose schedule of the National Acute Spinal Cord Injury Study Protocol (NASCIS-2), which consists of initial intravenous bolus, methyl prednisolone 30 mg/kg administered over 15 minutes, followed by a 45-minute pause before instituting the maintenance infusion of methyl prednisolone 5.
8% did not know that 15% potassium chloride solution should never be administered as intravenous bolus (Hsaio et al 2010).
30 minutes for the administration of a first benzodiazepine drug by intravenous bolus dosing; guidelines call for treatment within 5 minutes.