intravascular


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Related to intravascular: intravascular brachytherapy, Intravascular coagulation, intravascular fluid, Intravascular ultrasound, intravascular hemolysis

intravascular

 [in″trah-vas´ku-lar]
within a vessel or vessels.

in·tra·vas·cu·lar

(in'tră-vas'kyū-lăr),
Within the blood vessels or lymphatics.

intravascular

/in·tra·vas·cu·lar/ (in″trah-vas´ku-lar) within a vessel.

intravascular

(ĭn′trə-văs′kyə-lər)
adj.
Within blood vessels or a blood vessel.

in′tra·vas′cu·lar·ly adv.

intravascular

[-vas′kyələr]
Etymology: L, intra + vasculum, little vessel
pertaining to the inside of a blood vessel.

intravascular

adjective Within a blood vessel.

hemoglobinuria

Hematology The presence of Hb in the urine which, if of sufficient quantity, colors urine, the intensity of which directly correlates with the quantity of Hb. See Paroxysmal cold hemoglobinuria, Paroxysmal nocturnal hemoglobinuria.
hemolysis Destruction or lysis of RBCs
Hemolysis
Intracorpuscular hemolysis
•  Membrane defects, eg hereditary elliptocytosis, spherocytosis, stomatocytosis and paroxysmal nocturnal hemoglobinuria
•  Metabolic defects, eg G6PD, pyruvate kinase deficiency
•  Abnormal Hbs see Hemoglobin.
Extracorpuscular hemolysis
1º immune reactions, eg autoimmune hemolytic anemia
2º immune reactions, due to
• Infections, eg Bartonella, Clostridia, malaria, sepsis
• Neoplasia, eg lymphoma, leukemias
• Drug reactions due to the 'Innocent bystander' phenomenon (drug-antibody complex activates complement, causing intravascular hemolysis, eg quinidine), hapten-mediated —a protein-bound drug attaches to the red cell membrane, eliciting an immune response when the hapten-protein complex is recognized as foreign, evoking an immune response, eg penicillin acting as a hapten
• Induction of autoimmunity by RBC antigen alterations, eg Rh antigen
Physical, eg thermal, concentrated glycerol due to inadequate washing of frozen blood, bladder irrigation, cardiac valves
Extravascular Less severe, IgG-mediated and does not activate complement, eg Rh, Kell, Duffy Laboratory ↓ haptoglobin, ↓ T1/2 of circulating RBCs, ↑ indirect BR as liver capacity to conjugate BR–ergo direct BR is overwhelmed by massive hemolysis, ↑ LDH, Hb in blood and urine, hemosiderinuria, MetHb and metalbumin, ↑ urobilinogen in urine and feces, ↑ in acid phosphatase, K+, and prostatic acid phosphatase Clin Chem 1992; 38:575; peripheral smears demonstrate anisocytosis, polychromatophilia, nucleated RBCs, basophilic stippling; immune hemolysis is suggested by spherocytes NEJM 2000; 342:722cpc
Intravascular More severe, IgM-mediated and requires complement activation, eg ABO blood groups Laboratory ↑ free Hb  Note: Clinically significant hemolysis is usually detected by hemagglutination, less commonly by hemolysis per se, which detects anti-P,
-P1, -PP1Pk, -Jka, -Lea, occasionally also anti-Leb and -Vel

intravascular

Within a blood vessels within the lymphatics.

in·tra·vas·cu·lar

(IV) (in'tră-vas'kyū-lăr)
Within the blood vessels or lymphatics.

intravascular (in´trəvas´kūlur),

adj within a blood vessel.

intravascular

within a vessel or vessels.

disseminated intravascular coagulation
see disseminated intravascular coagulation.
intravascular fluid
that part of the total body fluid that is within the vascular system.
intravascular space
the space occupied by the blood.
References in periodicals archive ?
The current case of IVL is unusual because this patient had a prominent, diffuse intravascular component of tumor cells associated with a significant extravascular component.
Procurement Assignment of Framework Agreements in Order to Conclude Supply Contracts Subsequent Human Normal Immunoglobulin for Intravascular Administration
SAN DIEGO -- Cytori Therapeutics (NASDAQ: CYTX) has received a CE Mark in Europe for Intravase([R]), a reagent intended to be used with Cytori's Celution([R]) System for preparing safe and optimized adipose-derived stem and regenerative cells (ADRCs) for intravascular delivery into the same patient.
Intravascular large B-cell lymphoma is rare, occurring at an estimated frequency of less than 1 person per million.
a significant and proven advance in the field of intravascular imaging.
In 1923, Masson first described a benign intravascular lesion consisting of intravascular papillary hyperplasia and secondary thrombosis.
Given the imaging findings and intravascular hemolysis caused by a dysfunctional mitral valve, the most likely cause for the renal MRI findings was renal hemosiderosis.
The central line bundle as defined by the IHI is 'a group of evidence-based interventions for patients with intravascular central line catheters that, when implemented together, result in better outcomes than when implemented individually'.
Q In my laboratory, we are suddenly getting quite a few requests for disseminated intravascular coagulation-(DIC) related testing.
This time course was more suggestive of systemic absorption rather than intravascular injection.
Abstract: A new technology for intravascular temperature modulation increasingly is being used for severely ill neurosurgical patients in tertiary care centers in the United States.

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