2) It is believed to be caused by frequent repetitive increases in intrapharyngeal
pressure (such as occurs in glass blowers and trumpet players) and by the loss of muscle resilience associated with increasing age.
Moreover, a noncompliant, fibrotic CP muscle may predispose a patient to the formation of Zenker's diverticulum because of the increased intrapharyngeal
pressure caused by the functional obstruction.
RESULTS: A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice.
To screen for systemic oxidative effects of SWCNT exposure, Ho1-luc reporter mice or C57BL/6 mice (at least 4 mice per treatment) were exposed to SWCNT in doses of 10-40 [micro]g/mouse by single intrapharyngeal instillation and were sacrificed at time points including 1, 7, 28, and 56 days after exposure.
In those studies, cotton rats treated with Viprovex displayed diminished intrapulmonary and intrapharyngeal
viral titers as well as enhanced well-being (as evidenced by weight gain and temperature maintenance).
Increased nasal airflow resistance due to rhinitis leads to exaggerated intrapharyngeal
pressure during inspiration, which may in turn result in oropharyngeal collapse, much like when one sucks too hard on a straw, Dr.
Like most other instrumentalists, brass players are subject to entrapment neuropathies and dystonias, but they also have more serious neurologic risks resulting from the elevated intrapharyngeal
, intrathoracic, and intraabdominal pressures.
Two factors are relevant to the etiology of LPD: a loss of muscle elasticity with increasing age and an increase in intrapharyngeal
An experiment in hyperlipidemic rabbits showed that intrapharyngeal
instillation of ambient urban P[M.
7) High intrapharyngeal
pressures caused by coughing, vomiting, convulsions, or air infusion have been described as mechanisms by which air is forced into the tissues of the neck.
1,4) A loss of muscle elasticity with aging, a previous surgery, and an increase in intrapharyngeal
pressure all play important roles in the pathogenesis of this anomaly.
The normally high resistance of the nose in transnasal inspiration results in the introduction of subatmospheric intrapharyngeal
pressure, and the transmural pressure of the pharynx tends to close the airway.