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intranasal |
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| Archimedes believes intranasal delivery offers significant potential benefits in the treatment of breakthrough cancer pain and will represent an advance over oral transmucosal presentations through its high acceptability and fast onset of action. The superior efficacy of inhaled versus intranasal zanamivir is referenced as support for the idea that the lower respiratory tract is the preferred site of influenza infection; however, 1 study cited is insufficiently powered, and the other 2 do not compare the intranasal and inhaled routes (5-7). They gave a similar group of volunteers the intranasal FluMist spray. |
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