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intramucosal carcinoma

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intramucosal carcinoma
Oncology A high-grade/severe dysplasia–CIS of the GI mucosa, which extends to the lamina propria


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TUMOR CATEGORY ISSUES The designations in the pathologic tumor size (pT) category describe the deepest point of penetration of tumor in the bowel wall, with pTis (in situ carcinoma) including both high-grade dysplasia (tumor cells confined within the basement membrane of the involved crypt) and intramucosal carcinoma (tumor cells that invade the lamina propria but do not extend beyond the muscularis mucosae).
For pTis (carcinoma in situ): specify as either (1) high-grade dysplasia/intraepithelial carcinoma (pTie) or (2) intramucosal carcinoma (pTim).
Therefore, for colorectal cancer, the terms intraepithelial carcinoma and intramucosal carcinoma are recommended as descriptive terms to subclassify pTis and to clarify the status of the tumor.
 
 
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