interstitial fluid

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in·ter·sti·tial flu·id

the fluid in spaces between the tissue cells, constituting about 16% of the weight of the body; closely similar in composition to lymph.
Synonym(s): tissue fluid

interstitial fluid

an extracellular fluid that fills the spaces between most of the cells of the body and provides a substantial portion of the liquid environment of the body. Formed by filtration through the blood capillaries, it is drained away as lymph. It closely resembles blood plasma in composition but contains less protein. Compare intracellular fluid, lymph, plasma.

in·ter·sti·tial flu·id

(in'tĕr-stish'ăl flū'id)
The fluid in spaces between the tissue cells, constituting about 16% of the weight of the human body; closely similar in composition to lymph.

interstitial fluid

Extracellular fluid lying is small spaces around and between cells.

interstitial fluid


intercellular fluid

a liquid (also called LYMPH when inside lymphatic vessels) that bathes all the cells of the body, and acts as a connecting link between the blood and the cells. An average human male with 42 litres of total body water would have about 7 litres of interstitial fluid.

Interstitial fluid

The fluid between cells in tissues. Referred to as the liquid subtance of the body.
Mentioned in: Lymphedema

interstitial fluid

fluid within interstices, constituting ∼16% of body weight


1. a liquid or gas; any liquid of the body.
2. composed of molecules which freely change their relative positions without separation of the mass.

allantoic fluid
the fluid contained within the allantois.
amniotic fluid
the fluid within the amnion that bathes the developing fetus and protects it from mechanical injury.
ascitic fluid
see ascites.
fluid balance
a state in which the volume of body water and its solutes (electrolytes and nonelectrolytes) are within normal limits and there is normal distribution of fluids within the intracellular and extracellular compartments. The total volume of body fluids should be about 60% of the body weight, and it should be distributed so that one-third is extracellular fluid and two-thirds intracellular fluid. Although this distribution remains constant in a healthy animal, there is continuous movement of fluid into and out of the various compartments. See also dehydration, water intoxication.
body f's
the fluids within the body, composed of water, electrolytes and nonelectrolytes. The volume and distribution of body fluids vary with age, sex and amount of adipose tissue. Throughout life there is a slow decline in the volume of body fluids; obesity decreases the relative amount of water in the body.
Although the body fluids are continuously in motion, moving in and out of the cells, tissue spaces and vascular system, physiologists consider them to be 'compartmentalized'. Fluid within the cell membranes is called intracellular fluid and comprises about two-thirds of the total body fluids. The remaining one-third is outside the cell and is called extracellular fluid. The extracellular fluid can be further divided into tissue fluid (interstitial fluid), which is found in the spaces between the blood vessels and surrounding cells, and intravascular fluid, which is the fluid component of blood.
The maintenance of a proper balance between the intracellular and extracellular fluid volumes is essential to health. In patients with heart failure and renal failure the balance becomes upset, producing either localized or generalized edema. Excessive fluid loss produces fluid volume deficit causing cellular dehydration and impaired cellular function.
Bouin's fluid
a histological fixative.
cerebrospinal fluid
the fluid contained within the ventricles of the brain, the subarachnoid space, and the central canal of the spinal cord. See also cerebrospinal fluid.
fluid dram
see fluid dram.
fluid extract
a liquid preparation of a vegetable drug, containing alcohol as a solvent or preservative, or both, of such strength that each milliliter contains the therapeutic constituents of 1 gram of the standard drug it represents.
fetal fluid
allantoic plus amniotic fluids.
interstitial fluid
the extracellular fluid bathing the cells in most tissues, excluding the fluid within the lymph and blood vessels.
isotonic fluid
having the same tonicity or osmotic pressure as blood.
lacrimal fluid
aqueous fluid secreted by the lacrimal glands; called also tears.
fluid line
in radiographs, the interface between fluid and gas, as in the gastrointestinal tract, will show as a straight line.
fluid loss
by vomiting, diarrhea, polyuria, water deprivation. See dehydration.
fluid mosaic model
the modern concept of the structure of a biological membrane developed by S.J. Singer and G.L. Nicolson. In it the membrane consists of protein molecules partly embedded in a discontinuous bilayer of phospholipids that form the matrix of a mosaic of functional cell units.
fluid ounce
see fluid ounce.
pericardial, pleural, peritoneal fluid
normally present in amounts sufficient only to lubricate the movement of viscera within the respective cavities. Composition similar to blood serum.
fluid replacement
see fluid therapy (below).
fluid restriction
the limitation of oral fluid intake to a prescribed amount for each 24-hour period.
fluid retention
see edema.
spinal fluid
the fluid within the spinal canal.
fluid splashing sounds
audible when gas and fluid are free in a cavity, e.g. abomasum in cases of abomasal displacement; can be elicited by shaking a small animal or part of a large animal (i.e. succussion) or by simultaneous percussion and auscultation.
synovial fluid
fluid therapy
aims to replace fluids lost by disease process or by restriction of intake, or to maintain a high rate of fluid excretion to ensure removal of toxins, or to administer therapeutic or anesthetic agents slowly over a long period. The amounts and route of administration vary with the need of the patient. Normal solutions include 5% dextrose and Ringer's solution; alkalinizing fluids include lactated Ringer's and 1.3% sodium bicarbonate; acidifying solutions include isotonic saline and 1.9% ammonium chloride.
fluid thrill
see thrill.
fluid volume deficit
an imbalance in fluid volume in which there is loss of fluid from the body not compensated for by an adequate intake of water. The major causes are: (1) insufficient fluid intake, and (2) excessive fluid loss from vomiting, diarrhea, suctioning of gastric contents, or drainage through operative wounds, burns or fistulae. Decreased volume in the intravascular compartment is called hypovolemia. Because water moves freely between the compartments, extracellular fluid deficit causes intracellular fluid deficit (cellular dehydration), which leaves the cells without adequate water to carry on normal function.
fluid volume excess
an overabundance of water in the interstitial fluid spaces or body cavities (edema) or an excess of fluid within the blood vessels (hypervolemia) and water intoxication.
Factors that contribute to the accumulation of edematous fluid are: (1) dilatation of the arteries, as occurs in the inflammatory process; (2) reduced effective osmotic pressure, as in hypoproteinemia, lymphatic obstruction and increased capillary permeability; (3) increased venous pressure, as in congestive heart failure, thrombophlebitis and cirrhosis of the liver; and (4) retention of sodium due to increased reabsorption of sodium by the renal tubules.
fluid wave
see thrill.


pertaining to or situated between parts or in the interspaces of a tissue.

atypical interstitial pneumonia
interstitial cell adenoma
see interstitial cell tumor (below).
interstitial cell-stimulating hormone
luteinizing hormone.
interstitial cell
the cells of the connective tissue of the ovary or the testis (Leydig's cells), which furnish the internal secretion of those structures.
interstitial cell tumor
a common testicular tumor in old dogs. Most are benign and not associated with any major clinical disturbances but there may be concurrent perianal gland neoplasms, infertility and rarely feminization or viciousness. Called also Leydig cell tumor or interstitial cell adenoma.
interstitial edema
edema of the interstitial interlobular tissue in the lung.
interstitial emphysema
pulmonary emphysema with air accumulated in the interlobular connective tissue; characteristic of emphysema in cattle.
interstitial fluid
the extracellular fluid bathing cells in most tissues, excluding the fluid within the lymph and blood vessels.
interstitial gland
of the ovary, consisting of polyhedral epithelioid cells in the stroma of the ovary and have characteristics of cells which produce steroids.
interstitial nephritis
interstitial fluid pressure
pressure exerted by the free interstitial fluid; if the pressure is negative this tends to suck fluid out of the vascular system and into the tissue space; if the pressure is greater than the intravascular pressure fluid tends to move out of the tissue space.
interstitial pneumonia
interstitial space
tissue space.
interstitial tissue
connective tissue between the cellular elements of a structure.
References in periodicals archive ?
Site-to-site variation of glucose in interstitial fluid samples and correlation to venous plasma glucose.
For further ex vivo validation of these cleavage events, we conducted the peptide cleavage assay by incubating synthetic peptides with tumor interstitial fluid (TIF) and CM of MDA-MB-231 cells.
Normal fluctuations in energy production lead to variations in lactate and pyruvate concentrations in the interstitial fluid.
p] /W is defined as the fraction of the total applied normal load W that is supported by the interstitial fluid when it pressurizes.
Venous edema (described by the case patient as a heaviness while walking): Excess low-viscosity, protein-poor interstitial fluid due to increased capillary filtration (which can lead to postthrombotic syndrome)
Sysmex handled development of technology for painless and stable extraction of interstitial fluid samples, while Toshiba was responsible for developing the biosensor chips and detection unit hardware for precisely measuring the minute amounts of glucose contained in the samples.
Argenta awoke in the middle of the night with an idea: He envisioned placing a sterile foam dressing onto a wound, sealing the wound site with an adhesive drape, and then running a tube from the dressing to a controlled vacuum unit, to remove infectious and other unwanted materials, such as interstitial fluid, from the site.
The weight of the baby and an increase in blood volume, interstitial fluid (edema or swelling) and intrauterine fluid combine to add significant pressure on the hip, knee and ankle joints of expecting women.
These alterations contribute to the pathogenesis of Alzheimer's and may represent combined effects of neuronal degeneration, microgliosis, oligodendrocyte injury, microcirculatory disease, interstitial fluid status, and edema, the researchers said.
Continuous glucose monitoring through interstitial fluid analysis is now available and appears to give a more representative picture of the glycemic variations typical for type 1 diabetes.
Usage: Worn like a watch, the device emits a small electrical current that passes across the skin, extracting a small amount of interstitial fluid that is absorbed into a single-use sensor on the back of the device.
These include shining an infrared light though a person's forearm or finger and drawing glucose from the interstitial fluid through the skin using a laser beam or extremely small needle.

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