interstitial cystitis

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Related to interstitial cystitis: Elmiron


inflammation of the urinary bladder; it may result from an ascending infection coming from the exterior of the body by way of the urethra, or from an infection descending from the kidney. A simple cystitis that does not involve the rest of the urinary tract is not as serious as the descending type in which the kidneys and ureters as well as the bladder are involved. Often cystitis is not an isolated infection but is a result of some other physical condition, such as urinary retention, calculi in the bladder, tumors, or neurologic diseases that impair normal bladder function.

Prevention of recurrent cystitis in females that is not attributable to abnormal structures or other factors mentioned previously may be achieved by good personal hygiene and the following measures: (1) always wipe the anal region from front to back after a bowel movement; (2) avoid wearing nylon pantyhose, tight slacks, or any clothing that traps perineal moisture and prevents evaporation; (3) do not wash underclothing in strong soap, and rinse underclothing well; (4) do not use bubble bath, perfumed soap, feminine hygiene sprays, or products containing hexachlorophene; (5) avoid prolonged bicycling, motorcycling, horseback riding, and traveling involving prolonged sitting, which can contribute to irritation of the urethral meatus and to development of an ascending cystitis; and (6) do not ignore vaginal discharge or other signs of vaginal infection.
Symptoms and Treatment. The most common symptoms of cystitis are dysuria, frequency and urgency of urination, and in some cases hematuria. Chills and fever indicate involvement of the entire urinary tract and are not symptomatic of uncomplicated cystitis. Treatment of acute cystitis consists of antimicrobials, forcing of fluids, and bed rest. Hot sitz baths give some relief of the discomfort, and spasms of the bladder wall may respond to an antispasmodic drug such as hyoscyamine. Chronic cystitis is more difficult to cure and may require surgical dilatation of the urethra to facilitate drainage of urine. In many cases removal of the underlying cause, such as chronic vaginal infection, relieves the cystitis.
cystitis col´li inflammation of the bladder and bladder neck.
hemorrhagic cystitis cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide or cyclophosphamide, or a complication of bone marrow transplantation.
interstitial cystitis a type seen mainly in women, with the inflammatory lesion a small patch of red to brown mucosa surrounded by a network of radiating vessels, usually in the vertex and involving the entire thickness of the wall. The lesions are known as Hunner's ulcers and often heal superficially so that they are difficult to detect.
radiation cystitis inflammatory changes in the urinary bladder caused by ionizing radiation; called also radiocystitis.

in·ter·sti·tial cys·ti·tis

a chronic inflammatory condition of unknown etiology involving the epithelium and muscularis of the bladder, resulting in reduced bladder capacity, pain relieved by voiding, and severe bladder irritative symptoms.
See also: Hunner ulcer.

interstitial cystitis (IC)

an inflammation of the bladder, believed to be associated with an autoimmune or allergic response. The bladder wall becomes inflamed, ulcerated, and scarred, causing frequent painful urination. Hematuria may occur. Treatment may include distension of the bladder and cauterization of the ulcers (if present), dietary modification, oral or intravesical medication, pain management, and alternative therapies such as acupuncture. Cystectomy with urinary diversion is rarely indicated. The condition occurs most often in women and may resemble the early stages of bladder cancer. Diagnosis is often by exclusion and may require cystoscopy and biopsy. Also called painful bladder syndrome. See also Hunner's ulcer.

interstitial cystitis

Urology Idiopathic bladder wall inflammation, primarily affecting ♀ Clinical Pain, pressure, tenderness around bladder, pelvis, perineum; urgency; ↓ bladder capacity; painful sexual intercourse; in ♂, discomfort, pain in penis, scrotum Diagnosis Hx, Sx, cystoscopy, biopsy; it is a Dx of exclusion Management Symptomatic therapy Complications Scarring, stiffening, ulceration, bleeding

in·ter·sti·tial cys·ti·tis

(in'tĕr-stish'ăl sis-tī'tis)
A chronic inflammatory condition of unknown etiology involving the mucosa and muscularis of the bladder, resulting in reduced bladder capacity, pain relieved by voiding, and severe bladder irritative symptoms.
See also: Hunner ulcer

Interstitial cystitis

Chronic inflammation of the bladder; sometimes associated with vulvodynia.
Mentioned in: Vulvodynia

interstitial cystitis,

n a chronic bladder condition resulting in recurring pain in the pelvic area. Possible causes include autoimmune response to bladder infection, bacteria that are not found in the urine, or irritating urine chemistry.


inflammation of the urinary bladder. The condition may result from an ascending infection coming from the exterior of the body by way of the urethra, or it may be caused by an infection descending from the kidney. Often cystitis is not an isolated infection but is rather a result of some other physical condition. For example, urinary retention, calculi in the bladder, tumors, or neurological diseases impairing the normal function of the bladder may lead to cystitis.
Clinical signs include freqency, pain on urination, blood-stained urine, a thickened bladder wall. Significant clinical pathology findings include hematuria, a high cell count indicative of inflammation, and a positive bacterial culture.

cystitis cystica
cystitis marked by the presence of submucosal cysts.
emphysematous cystitis
an occasional complication of diabetes mellitus in dogs and cats, caused by gas-forming bacteria.
epizootic equine cystitis
an Australian disease of horses similar to Sorghum spp. poisoning.
gangrenous cystitis
results from severe inflammation and ischemia; the bladder wall is green to black.
cystitis glandularis
mucin-secreting glands present in the mucosa in a case of cystitis.
hemorrhagic cystitis
hemorrhage is the main clinical feature.
interstitial cystitis
a lower urinary tract disease of women in which there is painful urination and hemorrhagic lesions in the bladder wall, but no cause can be diagnosed. A similar syndrome is believed to occur in cats.
polypoid cystitis
the mucosa is folded with polypoid projections.
References in periodicals archive ?
Immunological Response to, Nifedipine for the Treatment of Interstitial Cystitis.
Devise corrective measures for pipeline projects by understanding Interstitial Cystitis (Painful Bladder Syndrome) pipeline depth and focus of Indication therapeutics.
The diagnosis of interstitial cystitis revisited: Lessons learned from the National Institutes of Health Interstitial Cystitis Database study.
Parsons cited a study based on a potassium sensitivity test he developed for interstitial cystitis.
Interstitial cystitis affects about 700,000 people in the United States, but that may be a vast underestimate, depending on how the condition is defined.
Summary GlobalData's clinical trial report, "Interstitial Cystitis (Painful Bladder Syndrome) Global Clinical Trials Review, H2, 2013" provides data on the Interstitial Cystitis (Painful Bladder Syndrome) clinical trial scenario.
Antiproliferative factor seems the most promising of several markers being studied in the NIDDK's multicenter Interstitial Cystitis Clinical Trials Group/Research Network, she said.
Every year, an estimated 700,000 people are diagnosed with interstitial cystitis (IC)--a difficult diagnosis to make, he commented.
Dale Guyer shares with Post readers what his research and firsthand experience have yielded on a wide range of topics--from selecting the best drinking water to alternative approaches in treating interstitial cystitis, from the benefits of exercise in overall wellbeing to the importance of monitoring blood levels of lead in both children and adults.
GlobalData's clinical trial report, Interstitial Cystitis Global Clinical Trials Review, H2, 2011" provides data on the Interstitial Cystitis clinical trial scenario.
4, 2012 /PRNewswire-USNewswire/ -- To glean fresh insights about how complementary and alternative medicine (CAM) offers new approaches to managing chronic pain conditions like interstitial cystitis (IC), the Interstitial Cystitis Association(ICA) conducted the largest ever survey of IC patients in a scientific study.

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