interstitial cystitis

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Related to interstitial cystitis: Elmiron


inflammation of the urinary bladder; it may result from an ascending infection coming from the exterior of the body by way of the urethra, or from an infection descending from the kidney. A simple cystitis that does not involve the rest of the urinary tract is not as serious as the descending type in which the kidneys and ureters as well as the bladder are involved. Often cystitis is not an isolated infection but is a result of some other physical condition, such as urinary retention, calculi in the bladder, tumors, or neurologic diseases that impair normal bladder function.

Prevention of recurrent cystitis in females that is not attributable to abnormal structures or other factors mentioned previously may be achieved by good personal hygiene and the following measures: (1) always wipe the anal region from front to back after a bowel movement; (2) avoid wearing nylon pantyhose, tight slacks, or any clothing that traps perineal moisture and prevents evaporation; (3) do not wash underclothing in strong soap, and rinse underclothing well; (4) do not use bubble bath, perfumed soap, feminine hygiene sprays, or products containing hexachlorophene; (5) avoid prolonged bicycling, motorcycling, horseback riding, and traveling involving prolonged sitting, which can contribute to irritation of the urethral meatus and to development of an ascending cystitis; and (6) do not ignore vaginal discharge or other signs of vaginal infection.
Symptoms and Treatment. The most common symptoms of cystitis are dysuria, frequency and urgency of urination, and in some cases hematuria. Chills and fever indicate involvement of the entire urinary tract and are not symptomatic of uncomplicated cystitis. Treatment of acute cystitis consists of antimicrobials, forcing of fluids, and bed rest. Hot sitz baths give some relief of the discomfort, and spasms of the bladder wall may respond to an antispasmodic drug such as hyoscyamine. Chronic cystitis is more difficult to cure and may require surgical dilatation of the urethra to facilitate drainage of urine. In many cases removal of the underlying cause, such as chronic vaginal infection, relieves the cystitis.
cystitis col´li inflammation of the bladder and bladder neck.
hemorrhagic cystitis cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide or cyclophosphamide, or a complication of bone marrow transplantation.
interstitial cystitis a type seen mainly in women, with the inflammatory lesion a small patch of red to brown mucosa surrounded by a network of radiating vessels, usually in the vertex and involving the entire thickness of the wall. The lesions are known as Hunner's ulcers and often heal superficially so that they are difficult to detect.
radiation cystitis inflammatory changes in the urinary bladder caused by ionizing radiation; called also radiocystitis.

in·ter·sti·tial cys·ti·tis

a chronic inflammatory condition of unknown etiology involving the epithelium and muscularis of the bladder, resulting in reduced bladder capacity, pain relieved by voiding, and severe bladder irritative symptoms.
See also: Hunner ulcer.

interstitial cystitis (IC)

an inflammation of the bladder, believed to be associated with an autoimmune or allergic response. The bladder wall becomes inflamed, ulcerated, and scarred, causing frequent painful urination. Hematuria may occur. Treatment may include distension of the bladder and cauterization of the ulcers (if present), dietary modification, oral or intravesical medication, pain management, and alternative therapies such as acupuncture. Cystectomy with urinary diversion is rarely indicated. The condition occurs most often in women and may resemble the early stages of bladder cancer. Diagnosis is often by exclusion and may require cystoscopy and biopsy. Also called painful bladder syndrome. See also Hunner's ulcer.

interstitial cystitis

Urology Idiopathic bladder wall inflammation, primarily affecting ♀ Clinical Pain, pressure, tenderness around bladder, pelvis, perineum; urgency; ↓ bladder capacity; painful sexual intercourse; in ♂, discomfort, pain in penis, scrotum Diagnosis Hx, Sx, cystoscopy, biopsy; it is a Dx of exclusion Management Symptomatic therapy Complications Scarring, stiffening, ulceration, bleeding

in·ter·sti·tial cys·ti·tis

(in'tĕr-stish'ăl sis-tī'tis)
A chronic inflammatory condition of unknown etiology involving the mucosa and muscularis of the bladder, resulting in reduced bladder capacity, pain relieved by voiding, and severe bladder irritative symptoms.
See also: Hunner ulcer

Interstitial cystitis

Chronic inflammation of the bladder; sometimes associated with vulvodynia.
Mentioned in: Vulvodynia

interstitial cystitis,

n a chronic bladder condition resulting in recurring pain in the pelvic area. Possible causes include autoimmune response to bladder infection, bacteria that are not found in the urine, or irritating urine chemistry.


inflammation of the urinary bladder. The condition may result from an ascending infection coming from the exterior of the body by way of the urethra, or it may be caused by an infection descending from the kidney. Often cystitis is not an isolated infection but is rather a result of some other physical condition. For example, urinary retention, calculi in the bladder, tumors, or neurological diseases impairing the normal function of the bladder may lead to cystitis.
Clinical signs include freqency, pain on urination, blood-stained urine, a thickened bladder wall. Significant clinical pathology findings include hematuria, a high cell count indicative of inflammation, and a positive bacterial culture.

cystitis cystica
cystitis marked by the presence of submucosal cysts.
emphysematous cystitis
an occasional complication of diabetes mellitus in dogs and cats, caused by gas-forming bacteria.
epizootic equine cystitis
an Australian disease of horses similar to Sorghum spp. poisoning.
gangrenous cystitis
results from severe inflammation and ischemia; the bladder wall is green to black.
cystitis glandularis
mucin-secreting glands present in the mucosa in a case of cystitis.
hemorrhagic cystitis
hemorrhage is the main clinical feature.
interstitial cystitis
a lower urinary tract disease of women in which there is painful urination and hemorrhagic lesions in the bladder wall, but no cause can be diagnosed. A similar syndrome is believed to occur in cats.
polypoid cystitis
the mucosa is folded with polypoid projections.
References in periodicals archive ?
Interstitial cystitis in the UK: Results of a questionnaire survey of members of the Interstitial Cystitis Support Group.
Randomized, doubleblind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis.
The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/ chronic pelvic pain syndrome in men: Results of the RAND interstitial cystitis epidemiology male study.
Prelief has been, for several years now, a much-relied-upon product for persons with interstitial cystitis.
an IC sufferer and founder of the Interstitial Cystitis Association of America.
The expression of heat shock protein 60 is reduced in the bladder of patients with interstitial cystitis.
Interstitial cystitis is a challenging bladder condition because the cause is unknown, the diagnosis is difficult, and a cure is not available (Czarapata, 1994; Ratliff, Klulke, & McDougall, 1994; Webster, 1993).
It contains information on the causes, diagnosis, and treatment of interstitial cystitis as well as information on current research studies that aim to understand and treat the disorder.
Lowell Parsons of the University of California at San Diego has used an anticoagulant that coasts the bladder wall, and at the recent American Urololgical Association (AUA) meeting in Atlanta, Larrian Gillespire, who runs an interstitial cystitis clinic in the Los Angeles area, reported positive results with a three-drug regimen.
USPRwire, Fri May 29 2015] Global Markets Direct's, 'Interstitial Cystitis (Painful Bladder Syndrome) - Pipeline Review, H1 2015', provides an overview of the Interstitial Cystitis (Painful Bladder Syndrome)'s therapeutic pipeline.

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