Leydig cell tumour

(redirected from interstitial cell tumour)

Leydig cell tumour

An uncommon gonadal tumour, which is functionally active and secretes steroids, usually testosterone; benign and malignant Leydig cell tumours are separated based on histologic features.

Clinical findings
Usually affects males, with a bimodal peak at age 5–10 and between 30 and 60. Childhood presentation is classically associated with precocious puberty in males, due to testosterone secretion by the tumour. One-third of female patients with Leydig cell tumours develop progressive masculinisation, preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminisation, and often acne and hirsutism, voice deepening, clitoromegaly, hair recession, and increased muscle mass.

Malignant features
> 5 cm, infiltration, vascular invasion, necrosis,  pleomorphism.
References in periodicals archive ?
Giant adrenal myelolipoma and testicular interstitial cell tumour in a man with congenital 21-hydroxylase deficiency.

Full browser ?