hybridoma /hy·brid·o·ma/ (hi″brid-o´mah) a somatic cell hybrid formed by fusion of normal lymphocytes and tumor cells.
hybridoma
hybridoma [hi″brĭ-do´mah]
hy·brid·o·ma (h  br -d  m )n. A cell hybrid produced in vitro by the fusion of a lymphocyte that produces antibodies and a myeloma tumor cell. It proliferates into clones that produce a continuous supply of a specific antibody. |
hybridoma
[hī′bridō′mə]
a hybrid cell formed by the fusion of a myeloma cell and an antibody-producing cell. Hybridomas are used to produce monoclonal antibodies.
hybridoma [hi″brĭ-do´mah]
a somatic cell hybrid formed by fusion of normal lymphocytes and tumor (lymphoma) cells. B cell hybridomas are the most useful source of monoclonal antibodies; the hybridoma cells are able to produce antibody like the normal parent and to proliferate indefinitely in culture like the parent tumor cells.
hybridoma
a cell culture consisting of a clone of a hybrid cell formed by fusing cells of different kinds. Hybridomas formed from mouse B lymphocytes following inoculation of a particular antigen and myeloma cells are immortal and produce monoclonal antibodies to the inoculated antigen. Such antibodies have produced a revolution in the level at which antibody-antigen reactions can be analyzed leading to precise definition of important epitopes, to methods for purifying antigens, improved diagnostic methods and, it is anticipated, to new methods of therapy.
interspecific hybridoma
one formed by fusion of cells from two different species, such as mouse and rat or hamster.
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