international normalized ratio


Also found in: Dictionary, Thesaurus, Financial, Acronyms, Encyclopedia.
Related to international normalized ratio: INR

international normalized ratio (INR),

the prothrombin time ratio that would have been obtained if a standard reagent had been used in a prothrombin time determination; the prothrombin time ratio is expressed as the patient prothrombin time divided by the mean of the prothrombin time reference interval; the prothrombin time ratio is obtained for a working reagent in the laboratory through use of a parameter designated the international sensitivity index. Compare: international sensitivity index.

international normalized ratio

(ĭn′tər-năsh′ə-nəl)
n.
A standardized measure of the clotting ability of blood based on the ratio of an individual's prothrombin time to the normal mean prothrombin time, used especially to monitor the risk of bleeding in patients receiving anticoagulant therapy.

International Normalized Ratio (INR)

a comparative rating of a patient's prothrombin time (PT) ratio, used as a standard for monitoring the effects of warfarin. The INR indicates what the patient's PT ratio would have been if measured by using the primary World Health Organization International Reference reagent.

International Normalized Ratio

Hematology A method of reporting prothrombin time–PT results for Pts receiving oral anticoagulant therapy; the INR is defined by the formula, PTPatient/PTMNPTISI that uses the international sensitivity index to adjust PT results from thromboplastin of different sources and facilitates monitoring anticoagulant therapy when using more than one lab and comparing a Pt's PT results with published standards for treatment. See Anticoagulation, International sensitivity index, Prothrombin time.

in·ter·na·tion·al nor·mal·ized ra·ti·o

(INR) (in'tĕr-nash'ŭn-ăl nōr'măl-īzd rā'shē-ō)
The prothrombin time ratio that would have been obtained if a standard reagent had been used in a prothrombin time determination; the prothrombin time ratio is expressed as the patient's prothrombin time divided by the mean of the prothrombin time reference interval; the prothrombin time ratio is obtained for a working reagent in the laboratory through use of a parameter designated the international sensitivity index.
See also: international sensitivity index

INR

; international normalized ratio index of blood coagulability (normal INR = 1); anticoagulant therapy (e.g. warfarin) adjusts INR to 2-4 (i.e. anticoagulated blood takes twice to four times as long to clot)
References in periodicals archive ?
Discrepant sensitivity of thromboplastin reagents to clotting factor levels explored by the prothrombin time in patients on stable oral anticoagulant treatment: impact on the international normalized ratio system.
1 percent) were taking warfarin; all had an international normalized ratio of less than 1.
Vitamin K antagonist (VKA) therapy is routinely monitored by the international normalized ratio (INR), determined from the prothrombin time (PT) test result by a standard formula:
For patients taking warfarin, weekly at-home self-testing of international normalized ratio is no better than high-quality monthly clinic INR testing at preventing major adverse events, according to a new report.
Prothrombin time (PT), [4] expressed as international normalized ratio (INR), is the standard measurement procedure used to monitor the oral anticoagulant therapy (1,2).
She responded to IV heparin therapy and was given Coumadin with international normalized ratio monitoring.
Given the level of uncertainty, it is prudent to check international normalized ratio (INR) of anticoagulated patients 7-14 days after starting any herbal, dietary supplement, or weight-loss regimen.
WARNING: Ingestion of more than 3 grams of Omega-3 fatty acids per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR).
Patients were randomly assigned to receive either a once-daily, 20mg dose of rivaroxaban or a standard, adjusted dose of warfarin, with a target international normalized ratio (INR) of 23.
A recent study examined the accuracy of three newer-generation POC international normalized ratio (INR) monitors vs.
Also, there is considerable doubt as to whether control patients were equally managed post intervention, and there were no data on the international normalized ratio achieved.
For patients with an elevated international normalized ratio (INR) with mild or no bleeding, withhold the warfarin and recheck INR in 1 to 2 days; if INR >5, add oral vitamin K supplementation (C).

Medical browser ?
Full browser ?