interleukin-6


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in·ter·leu·kin-6

(in'tĕr-lū'kin),
A cytokine derived from macrophages and endothelial cells that increases synthesis and secretion of immunoglobulins by B lymphocytes; also induces acute-phase proteins. In hepatocytes, it induces acute-phase reactants.
Synonym(s): B-cell stimulatory factor 2, interferon-β2

interleukin-6 (IL-6)

a cytokine derived from fibroblasts, macrophages, and tumor cells. It is an antiviral protein that is also used in the treatment of some types of cancer. Also called beta2-interferon.

IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.

in·ter·leu·kin-6

(in'tĕr-lū'kin)
A cytokine derived from fibroblasts, macrophages, and tumor cells that increases synthesis and secretion of immunoglobulins by B lymphocytes.
Synonym(s): B-cell stimulatory factor 2.

interleukin-6

A CYTOKINE produced by HELPER T CELLS, MACROPHAGES, fibroblasts and MAST CELLS that promotes the growth and differentiation of B cells, T cells and blood stem cells and the induction of ACUTE PHASE PROTEINS.
References in periodicals archive ?
The extra angiotensin did not much affect the retinal vessels of mice lacking interleukin-6 but vessels in the normal mouse retina mimicked the inflammatory reaction found in diabetic retinopathy.
When interleukin-6 was reintroduced to the genetically altered mice, the damage mimicked that of the normal mice.
Caldwell said: "So when we knock out interleukin-6, we can block the effects of angiotensin II.
In both groups, interleukin-6 was significantly higher at 8 hours and following delivery, compared with the baseline measurement, but no significant differences were found between the two groups in interleukin-6 levels at any of the measurement intervals.
68[degrees] C, respectively), their umbilical cord serum interleukin-6 levels were statistically the same as the afebrile group.
We agree with reports that suggest that maternal serum interleukin-6 levels rise in response to labor.
This thinking holds that epidural-related fever is the product of changes in thermoregulatory mechanisms, and that increases in proinflammatory cytokines such as interleukin-6 occur in normal pregnancy and labor.
In addition, smoke-exposed mice fed antioxidant supplements showed significantly lower production of interleukin-6 compared to smoke-exposed mice on a control diet.
The report includes a compilation of currently active projects in research and development of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) antagonists.
Another four antibodies against interleukin-6 or its receptor are also in clinical development and several other biologics in preclinical stages are advancing towards phase I.
In vivo vitamin E administration attenuates interleukin-6 and interleukin-1beta responses to an acute inflammatory insult in mouse skeletal and cardiac muscle.
Adherence to the Mediterranean diet was associated with reduced levels of interleukin-6 (P<0.