interleukin-12


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in·ter·leu·kin-12

(in'tĕr-lū'kin),
A cytokine derived from B lymphocytes and macrophages that induces γ-interferon (IFNγ) gene expression and IL-2 in T lymphocytes and natural killer cells and down-regulates Th2 cytokines.

interleukin-12 (IL-12)

a protein produced by activated T cells that stimulates cell-mediated killing by natural killer cells and lymphocytes. It promotes the maturation of cytotoxic T cells.

in·ter·leu·kin-12

(in'tĕr-lū'kin)
A cytokine derived from B lymphocytes, T lymphocytes, and macrophages that induces interferon-γ gene expression in T lymphocytes and natural killer cells.

interleukin-12

A CYTOKINE produced by T LYMPHOCYTES that inactivates natural killer cells.
References in periodicals archive ?
More important, the researchers have largely pieced together how these microbial products ignite autoimmunity Macrophages and other immune cells that are the first to respond to infections react to the bacterial material by producing interleukin-12.
With the microcapsule, the drug can be injected or sprayed where desired, and the nanocoating and microcapsule prolong the half-life of interleukin-12," the researcher added.
Like the interleukin-12 injections, a new experimental vaccine aims to stop malaria parasites before they stream from the liver.
Interleukin-12 (IL-12) can increase the number of these critical cells within tumors.
STELARA is a fully human monoclonal antibody with a novel mechanism of action that targets the p40 subunit of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23).
Ustekinumab is a fully human monoclonal antibody with a novel mechanism of action that targets the cytokines interleukin-12 and interleukin-23; formerly known as CNTO 1275, it was discovered by Centocor Inc.
These immune cells have a number of roles, such as producing interleukin-12 (IL-12), a molecule needed to trigger a strong lymphocyte response.
However, Enbrel's positioning in the psoriasis treatment algorithm is becoming more vulnerable in light of increasing competition from newer entrants such as Abbott's Humira (adalimumab) and Janssen Biotech's interleukin-12 and -23 (IL-12/23) inhibitor Stelara (ustekinumab), both of which offer efficacy superior to that of Enbrel.
ImmunoPulse(TM) IL-12, which employs intratumoral electroporation to enhance delivery of DNA-based interleukin-12 (IL-12), is designed to promote an anti-tumor immune response.
STELARA, the first in a new class of biologics for the treatment of psoriasis, works by targeting interleukin-12 (IL-12) and IL-23.
The antibody targets both interleukin-12 and interleukin-23.